Preparation of 5-heteroaryl substituted 1-(4-fluorophenyl)-1H-indoles via palladium-catalyzed Negishi and Stille cross-coupling reactions

被引：0
|
作者：
Balle, T
Andersen, K
Vedso, P
机构：
[1] H Lundbeck & Co AS, Dept Combinatorial Chem, DK-2500 Valby, Denmark
[2] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark
来源：
SYNTHESIS-STUTTGART | 2002年 / 11期
关键词：
indoles; Negishi reaction; Stille reaction; cross-coupling; palladium;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed Negishi cross-coupling of 5-1-(4-fluorophenyl)indolylzinc chloride with N-methyl-halopyrazoles, bromopyridines and bromopyrimidines in grant scale gave the corresponding cross-coupled products in 38-85% yield.
引用
收藏
页码：1509 / 1512
页数：4
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