In vitro antioxidant activity and in vivo wound-healing effect of lecithin liposomes: a comparative study

被引：36

作者：

Nasab, Maryam Eskandari ^{[1
]}

Takzaree, Nasrin ^{[2
,3
]}

Saffaria, Partow Mirzaee ^{[2
,3
]}

Partoazar, Alireza ^{[1
,4
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Med, Med Plants Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2019年 / 8卷 / 08期

关键词：

ABTS; antioxidant; DPPH; lecithin; liposome; nano size; wound healing; SOY LECITHIN; OXIDATIVE STABILITY; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; INFLAMMATION; CURCUMIN; STRESS; BETA; PH;

D O I：

10.2217/cer-2018-0128

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aim: This study was conducted to determine the potentials of egg lecithin (egg-l) and soy lecithin (soy-l) liposomes in antioxidative and wound healing properties. Materials & methods: The suspensions of egg-l and soy-l were prepared using the fusion technique. The free radical scavenging activity of both lecithin liposomes was evaluated by DPPH and ABTS methods. Tissue staining was used to assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend of 1-10mg/ml in radical-scavenging activities (p<0.0001). Wound-healing assessments showed a significant effect (p<0.0001) in treatment with topical lecithin liposomes. The results of wound healing also showed better outcomes of egg-l in comparison with phenytoin 1% cream. Conclusion: Antioxidant lecithin liposomes may enhance the treatment of wound injuries.

引用

页码：633 / 643

页数：11

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