Copper-Catalyzed C(sp2)-N Coupling of (E)-3-(2-Bromophenysl)-2-arylacrylamides for the Synthesis of 3-Arylquinolin-2-ones

被引：0

作者：

Jiang, Yi ^{[1
,2
]}

Gu, Jiayi ^{[1
,2
]}

Nie, Wenxing ^{[1
]}

Lu, Guoqing ^{[1
]}

Xin, Meixiu ^{[1
]}

Zhu, Zefeng ^{[3
]}

Jiang, Jiayao ^{[1
]}

Meng, Yingfen ^{[1
]}

Miao, Hui ^{[1
]}

Zou, Yong ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Guangdong Prov Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China

[3] Jinan Univ, Dept Pharm, Affiliated Hosp 5, Heyuan 517000, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 47期

基金：

中国国家自然科学基金;

关键词：

3-arylquinolin-2-ones; copper-catalyzed; C-N coupling; lactam; ligand-free; N BOND FORMATION; C-N; ARYL HALIDES; MICROWAVE CONDITIONS; FACILE SYNTHESIS; DIAMINE LIGANDS; AMINO-ACIDS; DERIVATIVES; AMIDATION; ARYLATION;

D O I：

10.1002/slct.202204339

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed, facile and efficient approach for the synthesis of 3-arylquinolin-2-ones starting from (E)-3-(2-bromophenyl)-2-arylacrylamides has been developed. Readily available starting materials, noble metal- and ligand-free conditions, as well as good tolerability for phenolic groups make this protocol attractive and practicable.

引用

页数：6

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