Copper-Catalyzed C(sp2)-N Coupling of (E)-3-(2-Bromophenysl)-2-arylacrylamides for the Synthesis of 3-Arylquinolin-2-ones

被引：0
|
作者：
Jiang, Yi [1 ,2 ]
Gu, Jiayi [1 ,2 ]
Nie, Wenxing [1 ]
Lu, Guoqing [1 ]
Xin, Meixiu [1 ]
Zhu, Zefeng [3 ]
Jiang, Jiayao [1 ]
Meng, Yingfen [1 ]
Miao, Hui [1 ]
Zou, Yong [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China
[2] Guangdong Prov Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China
[3] Jinan Univ, Dept Pharm, Affiliated Hosp 5, Heyuan 517000, Peoples R China
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 47期
基金：
中国国家自然科学基金;
关键词：
3-arylquinolin-2-ones; copper-catalyzed; C-N coupling; lactam; ligand-free; N BOND FORMATION; C-N; ARYL HALIDES; MICROWAVE CONDITIONS; FACILE SYNTHESIS; DIAMINE LIGANDS; AMINO-ACIDS; DERIVATIVES; AMIDATION; ARYLATION;
D O I：
10.1002/slct.202204339
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed, facile and efficient approach for the synthesis of 3-arylquinolin-2-ones starting from (E)-3-(2-bromophenyl)-2-arylacrylamides has been developed. Readily available starting materials, noble metal- and ligand-free conditions, as well as good tolerability for phenolic groups make this protocol attractive and practicable.
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页数：6
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