Protective Role of Melatonin in Liver Damage

被引：1
作者：
Chojnacki, Cezary [1 ]
Walecka-Kapica, Ewa [2 ]
Romanowski, Marek [1 ]
Chojnacki, Jan [1 ]
Klupinska, Grazyna [2 ]
机构：
[1] Med Univ Lodz, Dept Gastroenterol, PL-90647 Lodz, Poland
[2] Med Univ Lodz, Dept Clin Nutr, PL-90647 Lodz, Poland
来源：
CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 30期
关键词：
Melatonin; liver damage; steatohepatitis; liver cirrhosis; hepatic encephalopathy; ARYLALKYLAMINE-N-ACETYLTRANSFERASE; CIRCADIAN LOCOMOTOR-ACTIVITY; BILE-DUCT LIGATION; OXIDATIVE STRESS; CARBON-TETRACHLORIDE; LIPID-PEROXIDATION; PLASMA MELATONIN; NONALCOHOLIC STEATOHEPATITIS; INDUCED HEPATOTOXICITY; SYNTHESIZING ENZYMES;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirmed the melatonin, as well as it precursor tryptophan, protect the liver from non-alcoholic liver disease and also during the surgical procedure of partial liver resection.
引用
收藏
页码：4828 / 4833
页数：6
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