Protective Role of Melatonin in Liver Damage

被引：1

作者：

Chojnacki, Cezary ^{[1
]}

Walecka-Kapica, Ewa ^{[2
]}

Romanowski, Marek ^{[1
]}

Chojnacki, Jan ^{[1
]}

Klupinska, Grazyna ^{[2
]}

机构：

[1] Med Univ Lodz, Dept Gastroenterol, PL-90647 Lodz, Poland

[2] Med Univ Lodz, Dept Clin Nutr, PL-90647 Lodz, Poland

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 30期

关键词：

Melatonin; liver damage; steatohepatitis; liver cirrhosis; hepatic encephalopathy; ARYLALKYLAMINE-N-ACETYLTRANSFERASE; CIRCADIAN LOCOMOTOR-ACTIVITY; BILE-DUCT LIGATION; OXIDATIVE STRESS; CARBON-TETRACHLORIDE; LIPID-PEROXIDATION; PLASMA MELATONIN; NONALCOHOLIC STEATOHEPATITIS; INDUCED HEPATOTOXICITY; SYNTHESIZING ENZYMES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirmed the melatonin, as well as it precursor tryptophan, protect the liver from non-alcoholic liver disease and also during the surgical procedure of partial liver resection.

引用

页码：4828 / 4833

页数：6

共 118 条

[1] Role of melatonin in the oxidative damage prevention at different times of hepatic regeneration [J].

Aida Gonzalez, Marcela ;

del Carmen Contini, Mara ;

Millen, Nestor ;

Teresita Mahieu, Stella .

CELL BIOCHEMISTRY AND FUNCTION, 2012, 30 (08) :701-708

[2]

Aktas C, 2012, TOXICOL IND HLTH, P24

[3] Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reperfusion injury [J].

Amine Zaouali, Mohamed ;

Reiter, Russel J. ;

Padrissa-Altes, Susagna ;

Boncompagni, Eleonora ;

Garcia, Joaquin J. ;

ben Abnennebi, Hassen ;

Freitas, Isabel ;

Garcia-Gil, Francisco A. ;

Rosello-Catafau, Joan .

JOURNAL OF PINEAL RESEARCH, 2011, 50 (02) :213-221

[4] Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering [J].

Aravamudhan, Aja ;

Ramos, Daisy M. ;

Nip, Jonathan ;

Subramanian, Aditi ;

James, Roshan ;

Harmon, Matthew D. ;

Yu, Xiaojun ;

Kumbar, Sangamesh G. .

CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (19) :3420-3428

[5]

Ardizzi A, 1998, Minerva Med, V89, P1

[6] PLASMA MELATONIN LEVELS IN ANOREXIA-NERVOSA [J].

ARENDT, J ;

BHANJI, S ;

FRANEY, C ;

MATTINGLY, D .

BRITISH JOURNAL OF PSYCHIATRY, 1992, 161 :361-364

[7] Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics [J].

Basile, M ;

Romeo, C ;

Gitto, E ;

Spitz, L ;

Pierro, A ;

Eaton, S .

PEDIATRIC SURGERY INTERNATIONAL, 2004, 20 (04) :263-266

[8] Sulphatoxymelatonin excretion in older people: Relationship to plasma melatonin and renal function [J].

Baskett, JJ ;

Cockrem, JF ;

Antunovich, TA .

JOURNAL OF PINEAL RESEARCH, 1998, 24 (01) :58-61

[9] AMPLIFICATION OF NOCTURNAL MELATONIN SECRETION IN WOMEN WITH FUNCTIONAL HYPOTHALAMIC AMENORRHEA [J].

BERGA, SL ;

MORTOLA, JF ;

YEN, SSC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (01) :242-244

[10] Melatonin reduces nitric oxide synthase activity in rat hypothalamus [J].

Bettahi, I ;

Pozo, D ;

Osuna, C ;

Reiter, RJ ;

AcunaCastroviejo, D ;

Guerrero, JM .

JOURNAL OF PINEAL RESEARCH, 1996, 20 (04) :205-210

← 1 2 3 4 5 6 7 8 9 10 →