Effect of alpha-melanotropin hormone on serum levels of luteinizing hormone and progesterone in experimental rat autoimmune oophoritis

被引：5

作者：

Berberian, Victoria

Sanchez, Silvina

Sanchez-Borzone, Mariela

Attademo, Andres M.

Lasaga, Mercedes

Celis, Maria Ester ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Med, Dept Farmacol, Lab Ciencias Fisiol, RA-5000 Cordoba, Argentina

[2] Univ Buenos Aires, Fac Med, Ctr Invest Reproducc, RA-1112 Buenos Aires, DF, Argentina

来源：

PEPTIDES | 2006年 / 27卷 / 09期

关键词：

experimental autoimmune; oophoritis; hormones; alpha-MSH effect; inflammatory process; icv injections;

D O I：

10.1016/j.peptides.2006.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied the effect of alpha-melanotropin hormone (alpha-MSH) on experimental autoimmune oophoritis (EAO), an inflammatory process induced in female rats. During proestrus, serum levels of LH and progesterone in rats with EAO were higher than those of control rats. However, administration of alpha-MSH to these rats decreased the levels of LH. Similarly, in the following diestrus, rats with EAO had high levels of LH but treatment with alpha-MSH decreased the levels to diestrus 2 control values. Treatment with alpha-MSH also reduced the LH levels of control rats in diestrus 2 compared to untreated controls. However, alpha-MSH treatment had no effect on progesterone levels of either control or rats with EAO. Thus, although alpha-MSH induced notable changes in levels of LH, this decrease was unable to block the illness. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：2295 / 2299

页数：5

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