Bioactive phenazines from an earwig-associated Streptomyces sp.

被引：14

作者：

Han Hao ^{[1
]}

Guo Zhi-Kai ^{[2
]}

Zhang Bo ^{[1
]}

Zhang Mei ^{[1
]}

Shi Jing ^{[1
]}

Li Wei ^{[1
]}

Jiao Rui-Hua ^{[1
]}

Tan Ren-Xiang ^{[1
,3
]}

Ge Hui-Ming ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China

[3] Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 06期

关键词：

Earwig-associated actinomycete; Phenazine; Biosynthetic pathway; Antimicrobial activity; Acetylcholinesterase inhibitory activity; PSEUDOMONAS-FLUORESCENS; IN-VITRO; BIOSYNTHESIS; DERIVATIVES;

D O I：

10.1016/S1875-5364(19)30055-X

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a bio-synthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.

引用

页码：475 / 480

页数：6

共 21 条

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