Enantioselective Reaction Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s

被引：0

作者：

Nakamura, Shuichi ^{[1
]}

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Frontier Mat, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2015年 / 73卷 / 11期

关键词：

FRIEDEL-CRAFTS ALKYLATION; OPTICALLY-ACTIVE PROPARGYLAMINES; BAYLIS-HILLMAN REACTION; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; DECARBOXYLATIVE ADDITION; QUATERNARY STEREOCENTERS; 3-COMPONENT SYNTHESIS; MARINE ALKALOIDS; BENZYL NITRILES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of novel chiral catalysts is one of the most challenging areas in organic chemistry. This account summarizes our recent studies on chiral bis(imidazoline)-palladium pincer type catalysts (phebim-Pd). The catalysts can be used in the enantioselective reaction of a wide variety of nitrile compounds with imines giving products in high yields with good stereoselectivities. This process offers a simple and efficient route for the synthesis of functionalized beta-aminonitriles and their derivatives. We also examine the enantioselective allylation of ketimines derived from isatins using chiral phebim-Pd complexes to afford products in high yields with good enantioselectivities.

引用

页码：8 / 17

页数：10

共 100 条

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Abele S, 2000, EUR J ORG CHEM, V2000, P1

[2] SYNTHESIS AND CHARACTERIZATION OF 5-COORDINATE OLEFIN COMPLEXES OF PALLADIUM(II) - MOLECULAR-STRUCTURE OF THE ACETONE SOLVATE OF (2,9-DIMETHYL-1,10-PHENANTHROLINE)(MALEIC ANHYDRIDE)METHYLCHLOROPALLADIUM [J].