The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network 'Rete Ematologica del Lazio per i Linfomi' (RELLI)

被引：11

作者：

Annibali, Ombretta ^{[1
]}

Hohaus, Stefan ^{[2
]}

Marchesi, Francesco ^{[3
]}

Cantonetti, Maria ^{[4
]}

Di Rocco, Alice ^{[5
]}

Tomarchio, Valeria ^{[1
]}

Di Napoli, Arianna ^{[6
]}

Pelliccia, Sabrina ^{[7
]}

Battistini, Roberta ^{[8
]}

Borza, Paola Anticoli ^{[9
]}

Abruzzese, Elisabetta ^{[10
]}

Cenfra, Natalia ^{[11
]}

Andriani, Alessandro ^{[12
]}

Tesei, Cristiano ^{[7
]}

Alma, Eleonora ^{[2
]}

Palombi, Francesca ^{[3
]}

Pupo, Livio ^{[4
]}

Petrucci, Luigi ^{[5
]}

Becilli, Marco ^{[1
]}

Maiolo, Elena ^{[2
]}

Bellesi, Silvia ^{[2
]}

Cuccaro, Annarosa ^{[2
]}

D'Alo, Francesco ^{[2
]}

Cox, Maria Christina ^{[7
]}

机构：

[1] Univ Campus Bio Med Roma, Trapianto Cellule Staminali, Ematol, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Ist Ematol, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[3] IRCCS Ist Nazl Tumori Regina Elena, UO Ematol & Trapianto Cellule Staminali, Rome, Italy

[4] Policlin Tor Vergata Roma, UO Ematol, Rome, Italy

[5] Univ Sapienza Roma, Dipartimento Biotecnol Cellulari & Ematol, Rome, Italy

[6] Azienza Osped Univ, Anat Patol, Rome, Italy

[7] Azienza Osped Univ, Ematol, Rome, Italy

[8] UOC Ematol & Trapianti CSE AO San Camillo Forlani, Rome, Italy

[9] Osped San Giovanni Addolorata, SC Ematol & Trapianto Cellule Staminali, Rome, Italy

[10] Osped St Eugenio, Ematol, Rome, Italy

[11] Polo Univ Pontino, Ematol, Latina, Italy

[12] Osped Nuovo Regina Margherita, Rome, Italy

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 14期

关键词：

DLBCL; lymphoma; N; L ratio; R-CHOP; cancer; NEUTROPHIL; INFLAMMATION; RITUXIMAB; CANCER; COUNT; SURVIVAL; IMPROVES; INDEX; IPI;

D O I：

10.1080/10428194.2019.1633628

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio >= 3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).

引用

页码：3386 / 3394

页数：9

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