Hydrothermal alteration within the Mount Isa Block (MIB) is typically largely to have ceased at the end of the Isan Orogeny (ca. 1.50 Ga). However, late, large brittle quartz-rich vein systems, including those of the Cloncurry Fault, cut Mesoproterozoic tectonic fabrics, intrusions and products of regional Na-Ca hydrothermal alteration. Associated features display affinities to iron oxide-Cu-Au ore deposits, including specular hematite-bearing veins and Cu-(Au-U-LREE-Ba) mineralization. Stable isotope data suggest late veins in the vicinity of the Cloncurry Fault, Eastern Fold Belt (EFB), formed from fluids with delta(18)O(H2O) and deltaD(H2O) (250 degreesC) of -4parts per thousand to +3parts per thousand and -22parts per thousand to -4parts per thousand, respectively. The high deltaD(H2O), moderate delta(18)O(H2O) and CaCl2-NaCl-rich character of the saline fluids indicates they were mixtures of low-latitude meteoric fluids and evaporite-derived basinal brines, which, with time, became progressively dominated by meteoric water, deposited barite and cooled. The low-latitude meteoric signature demonstrates that the fault-fracture systems were active when in equatorial regions. Paleomagnetic data for the MIB, and the Australian protocontinent, together with structural and thermal considerations, and geochronological arguments suggest the veins probably formed sometime after 1.10 Ga, and potentially as late as during the Alice Springs Orogeny (ca. 0.34 Ga). The late quartz veining was unrelated to two phases of regional Na-Ca alteration and economically significant Fe oxide-Cu-Au mineralization at 1.60-1.58 and 1.53-1.50 Ga. (C) 2004 Elsevier B.V. All rights reserved