Age-related diagnostic utility of rheumatoid factor, anticyclic citrullinated peptide and antikeratin antibodies in Chinese patients with rheumatoid arthritis

被引：3

作者：

Lin, Jinpiao ^{[1
,2
]}

Liu, Can ^{[1
,2
]}

Yang, Bin ^{[1
,2
]}

Ou, Qishui ^{[1
,2
]}

机构：

[1] Fujian Med Univ, Affiliated Hosp 1, Dept Lab Med, Fuzhou 350005, Fujian, Peoples R China

[2] Fujian Med Univ, Affiliated Hosp 1, Genet Diagnost Lab, Fuzhou 350005, Fujian, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2014年 / 42卷 / 03期

关键词：

Rheumatoid arthritis; rheumatoid factor; anticyclic citrullinated peptide antibody; antikeratin antibody; JUVENILE IDIOPATHIC ARTHRITIS; AMERICAN-COLLEGE; JOINT DAMAGE; AUTOANTIBODIES; ASSOCIATION; SYNOVITIS;

D O I：

10.1177/0300060514524734

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives: Retrospective study to evaluate the diagnostic utility of rheumatoid factor (RF), anticyclic citrullinated peptide antibodies (ACPA) and antikeratin antibodies (AKA) in a broad age range of patients with rheumatoid arthritis (RA). Methods: Clinical and serological data from patients with RA were collected and analysed. Patients were stratified according to age (< 16 years [juvenile idiopathic arthritis; JIA], 16-40 years; 41-60 years and >60 years) and sex. Results: The study included 3725 patients. There were no significant sex-related differences in rates of RF, ACPA or AKA positivity. RF, ACPA and AKA positivity were significantly less common in patients aged < 16 years than those aged >= 16 years. There were no other significant differences between age groups. Conclusions: RF, ACPA and AKA have better diagnostic value for RA in adult patients than in patients with JIA. A combination of RF, ACPA and AKA serological testing may be a useful diagnostic tool for RA in Chinese adults.

引用

页码：711 / 717

页数：7