Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells

被引：706
作者：
Li, Y
Field, PM
Raisman, G
机构：
[1] Norman and Sadie Lee Research Centre, Natl. Institute for Medical Research, Medical Research Council
来源：
SCIENCE | 1997年 / 277卷 / 5334期
关键词：
D O I：
10.1126/science.277.5334.2000
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The upper cervical corticospinal tract was transected on one side in adult rats. A suspension of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site, This induced unbranched, elongative growth of the cut corticospinal axons, The axons grew through the transplant and continued to regenerate into the denervated caudal host tract, Rats with complete transections and no transplanted cells did not use the forepaw on the lesioned side for directed reaching, Rats in which the transplanted cells had formed a continuous bridge across the lesion exhibited directed forepaw reaching on the lesioned side.*
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页码：2000 / 2002
页数：3
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