Coagulation Disorders and Bleeding in Liver Disease: Future Directions

被引：11

作者：

Caldwell, Stephen H. ^{[1
]}

Sanyal, Arun J. ^{[2
]}

机构：

[1] Univ Virginia, Med Ctr, Digest Hlth Ctr Excellence, GI Hepatol Div, Charlottesville, VA 22908 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div GI Hepatol & Nutr, Richmond, VA 23298 USA

来源：

CLINICS IN LIVER DISEASE | 2009年 / 13卷 / 01期

关键词：

Coagulation; Bleeding; Cirrhosis; Liver disease; Hyperfibrinolysis; Dysfibrinogen; Heparinoids; INTERNATIONAL NORMALIZED RATIO; MODEL; CIRRHOSIS;

D O I：

10.1016/j.cld.2008.09.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Much has changed since the characterization of the wide spectrum of abnormalities in the coagulation system in patients who have acute and chronic liver disease. With inherent limitations of conventional laboratory measures of coagulation in liver disease, it is now incumbent on us to explore how best to apply (or withhold) specific agents in specific situations. This will clearly require well focused translational research to understand and bring into sharp focus the various problems present, from dysfibrinogen to endogenous heparinoids, to uremia, to hyperfibrinolysis and even to unrecognized hypercoagulable conditions. The challenge lies ahead.

引用

页码：155 / +

页数：4

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