Metformin prevents progression of pancreatic intraepithelial neoplasia to ductal adenocarcinoma by targeting cancer stem cells and mTOR signaling

被引：1
|
作者：
Mohammed, Altaf [1 ]
Brewer, Misty [1 ]
Ritchie, Rebekah L. [1 ]
Marya, Anuj [1 ]
Lightfoot, Stan [1 ]
Janakiram, Naveena B. [1 ]
Steele, Vernon E. [2 ]
Rao, Chinthalapally V. [1 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
[2] NCI, Bethesda, MD 20892 USA
来源：
CANCER RESEARCH | 2013年 / 73卷 / 08期
关键词：
D O I：
10.1158/1538-7445.AM2013-2268
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2268
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling
    Mohammed, Altaf
    Janakiram, Naveena B.
    Brewer, Misty
    Ritchie, Rebekah L.
    Marya, Anuj
    Lightfoot, Stan
    Steele, Vernon E.
    Rao, Chinthalapally V.
    TRANSLATIONAL ONCOLOGY, 2013, 6 (06): : 649 - U266
  • [2] Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia
    Umesh K Bhanot
    Hepatobiliary & Pancreatic Diseases International, 2008, (01) : 106 - 107
  • [3] Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia
    Bhanot, Umesh K.
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2008, 7 (01) : 106 - 107
  • [4] Pancreatic intraepithelial neoplasia in heterotopic pancreas - Evidence for the progression model of pancreatic ductal adenocarcinoma
    Zhang, Lizhi
    Sanderson, Schuyler O.
    Lloyd, Ricardo V.
    Smyrk, Thomas C.
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (08) : 1191 - 1195
  • [5] Progression to pancreatic ductal adenocarcinoma from pancreatic intraepithelial neoplasia: Results of a simulation model
    Peters, Mary Linton B.
    Eckel, Andrew
    Mueller, Peter P.
    Tramontano, Angela C.
    Weaver, Davis T.
    Lietz, Anna
    Hur, Chin
    Kong, Chung Yin
    Pandharipande, Pan, V
    PANCREATOLOGY, 2018, 18 (08) : 928 - 934
  • [6] Targeting mTOR in Pancreatic Ductal Adenocarcinoma
    Iriana, Sentia
    Ahmed, Shahzad
    Gong, Jun
    Annamalai, Alagappan Anand
    Tuli, Richard
    Hendifar, Andrew Eugene
    FRONTIERS IN ONCOLOGY, 2016, 6
  • [7] Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    Mazur, Pawel K.
    Einwaechter, Henrik
    Lee, Marcel
    Sipos, Bence
    Nakhai, Hassan
    Rad, Roland
    Zimber-Strobl, Ursula
    Strobl, Lothar J.
    Radtke, Freddy
    Kloeppel, Guenter
    Schmid, Roland M.
    Siveke, Jens T.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (30) : 13438 - 13443
  • [8] Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia
    Cheng, Ming-Fang
    Tsai, Wen-Chiuan
    Hsia, Kan-Tai
    Yang, Ya-Sung
    Jin, Jong-Shiaw
    APMIS, 2014, 122 (02) : 147 - 154
  • [9] Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia:report of a case
    Rajkumar Krishnasamy
    Shaleen Agarwal
    Shivendra Singh
    Sunil Puri
    Puja Sakhuja
    Anil K Agarwal
    Hepatobiliary & Pancreatic Diseases International, 2007, (05) : 553 - 556
  • [10] Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia(The Author reply)
    Anil K Agarwal
    Hepatobiliary&PancreaticDiseasesInternational, 2008, (02) : 221 - 221
12345