Angiotensinogen polymorphism and ischemic stroke risk

被引：0

作者：

Bao, Huan ^{[1
]}

Hao, Jun-Jie ^{[1
]}

Yang, Yu-Mei ^{[1
]}

Xu, Xia-Hong ^{[1
]}

Wang, Yue ^{[1
]}

Zuo, Lian ^{[1
]}

Lu, Jing ^{[1
]}

Zhang, Jing ^{[1
]}

Zhang, Yue ^{[1
]}

Xu, Si-Yi ^{[1
]}

Wang, Xuan ^{[1
]}

Li, Ying ^{[1
]}

Li, Gang ^{[1
]}

机构：

[1] Shanghai East Hosp, Dept Neurol, Shanghai 200123, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 08期

关键词：

Ischemic stroke; angiotensinogen; meta-analysis; genetic; CEREBROVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ALDOSTERONE SYSTEM; CONVERTING ENZYME; POPULATION; RENIN; GENES; DEATH;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The angiotensinogen M235T polymorphism was associated with ischemic stroke risk. However, the results were controversial. Thus, a meta-analysis was conducted. NCBI, Medline, Web of Science and Embase databases were systematically searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. There was a significant association between angiotensinogen M235T polymorphism and ischemic stroke risk (OR = 1.69; 95% CI, 1.35-2.11; P < 0.001). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with ischemic stroke in Asian (OR = 1.85; 95% CI, 1.45-2.35; P < 0.001). In the age subgroup, we found that angiotensinogen M235T polymorphism could increase both early-onset ischemic stroke risk (OR = 1.88; 95% CI, 1.33-2.43; P < 0.001) and late-onset ischemic stroke risk (OR = 1.20; 95% CI, 1.01-1.39; P = 0.04). This meta-analysis suggested that angiotensinogen M235T polymorphism was associated with ischemic stroke.

引用

页码：12914 / 12920

页数：7

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