New and established treatment options for mycosis fungoides and Sezary syndrome - an update

被引:14
|
作者
Dugas-Breit, Susanne [1 ]
Schulze, Hans-Joachim [1 ]
Hallermann, Christian [1 ]
机构
[1] Fachklin Hornheide, Dept Dermatol, D-48157 Munster, Germany
来源
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2014年 / 12卷 / 07期
关键词
T-CELL LYMPHOMA; TOPICAL NITROGEN-MUSTARD; ELECTRON-BEAM THERAPY; TERM-FOLLOW-UP; CUTANEOUS LYMPHOMA; PHASE-II; MARROW-TRANSPLANTATION; DISEASE PROGRESSION; ORAL ALITRETINOIN; MULTICENTER-TRIAL;
D O I
10.1111/ddg.12376
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sezary syndrome being the most frequent entities. A precise staging based on clinical, histological, immunohistological and molecular biological criteria is crucial for selecting the appropriate therapy. Since curative treatment is only possible in exceptional cases, the aim of any therapy is to achieve healing of the skin lesions, minimizing relapses, preventing progression and maintaining the quality of life. While in early disease stages skin-directed therapy is being used, in later stages systemic treatments become more important. This work aims to provide an overview of established and new therapies for the treatment of mycosis fungoides and Sezary syndrome.
引用
收藏
页码:561 / 569
页数:9
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