Can Pluripotent Stem Cells Be Used in Cell-Based Therapy?

被引：14

作者：

Picanco-Castro, Virginia ^{[1
]}

Moreira, Lilian F. ^{[1
]}

Kashima, Simone ^{[1
]}

Covas, Dimas T. ^{[1
]}

机构：

[1] Blood Ctr Ribeirao Preto, BR-14022000 Ribeirao Preto, Brazil

来源：

CELLULAR REPROGRAMMING | 2014年 / 16卷 / 02期

关键词：

HEPATOCYTE-LIKE CELLS; HUMAN FIBROBLASTS; SOMATIC-CELLS; DIFFERENTIATION; GENERATION; INDUCTION; IMMUNOGENICITY; VECTOR; LINES;

D O I：

10.1089/cell.2013.0072

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Pluripotent stem cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have the ability to differentiate into several cell types that can be used in drug testing and also in the study and treatment of diseases. These cells can be differentiated by in vitro systems, which may serve as models for human diseases and for cell transplantation. In this review, we address the pluripotent cell types, how to obtain and characterize these cells, and differentiation assays. We also focus on the potential of these cells in clinical trials, and we describe the clinical trials that are underway.

引用

页码：98 / 107

页数：10

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