State- and trait-related deficits in sustained attention in bipolar disorder

被引:116
作者
Clark, L
Goodwin, GM [1 ]
机构
[1] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England
[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
关键词
bipolar disorder; neuropsychology; attention; vigilance; mania;
D O I
10.1007/s00406-004-0460-y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Investigation of neuropsychological functioning in bipolar disorder provides a potential link from the prominent cognitive symptoms of the disorder to the underlying neural mechanisms. Continuous performance measures of sustained attention have yielded consistent findings in bipolar disorder patients. There are impairments that appear to be both state- and trait-related. Impaired target detection may represent one of the most sensitive markers of illness course in bipolar disorder. It is unrelated to residual mood symptomatology and medication status, and is present in patients with good functional recovery. The impairment in target detection is exacerbated in the manic state, and is accompanied by an increased rate of false responding. Sustained attention deficit is present early in the course of the disorder, but becomes more pronounced with repeated episodes. This cognitive profile, of an early-onset, state- modulated, trait marker, is distinct from the profile of attentional disruption seen in schizophrenia or unipolar depression. The state- and trait-related impairments may be differentially associated with the ascending dopamine and noradrenaline projections.
引用
收藏
页码:61 / 68
页数:8
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