FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway

被引：17

作者：

He, Shanyang ^{[1
,2
]}

Wang, Wei ^{[3
,4
]}

Wan, Zhiyong ^{[3
,4
]}

Shen, Hongwei ^{[3
,4
]}

Zhao, Yunhe ^{[3
,4
]}

You, Zeshan ^{[3
,4
]}

Liu, Jun ^{[3
,4
]}

Zhu, Liwen ^{[3
,4
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou 510080, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China

[3] Guangdong Prov Peoples Hosp, Dept Obstet & Gynecol, Guangzhou 510080, Guangdong, Peoples R China

[4] Guangdong Acad Med Sci, Guangzhou 510080, Guangdong, Peoples R China

来源：

ONCOGENESIS | 2021年 / 10卷 / 01期

关键词：

PROGNOSIS; DOMAIN;

D O I：

10.1038/s41389-020-00301-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin resistance is frequently occurred in ovarian cancer therapy, understanding its regulatory mechanisms is critical for developing novel treatment methods and drugs. Here, we found ovarian cancer patients with low FAM83B levels had shorter survival time, tissues with cisplatin resistance also had low FAM83B levels, suggesting FAM83B might inhibit cisplatin resistance. FAM83B overexpression inhibits cisplatin resistance showed in increased ovarian cancer cell proliferation and growth rate, and reduced apoptosis rate, while FAM83B knockdown promotes cisplatin resistance. Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway activity in clinic samples, confirming FAM83B inhibited Wnt pathway activity. In summary, we found FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway, providing a new target for ovarian cancer therapy.

引用

页数：10

共 24 条

[1] Adenosine Analogues as Opposite Modulators of the Cisplatin Resistance of Ovarian Cancer Cells
Bednarska-Szczepaniak, Katarzyna
Krzyianowski, Damian
Klink, Magdalena
Nowak, Marek
[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2019, 19 (04) : 473 - 486
[2] The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members
Breitman, Maya
Zilberberg, Alona
Caspi, Michal
Rosin-Arbesfeld, Rina
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (10): : 1792 - 1802
[3] Biochemical Mechanisms of Cisplatin Cytotoxicity
Cepeda, Victoria
Fuertes, Miguel A.
Castilla, Josefina
Alonso, Carlos
Quevedo, Celia
Perez, Jose M.
[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2007, 7 (01) : 3 - 18
[4] Conserved Oncogenic Behavior of the FAM83 Family Regulates MAPK Signaling in Human Cancer
Cipriano, Rocky
Miskimen, Kristy L. S.
Bryson, Benjamin L.
Foy, Chase R.
Bartel, Courtney A.
Jackson, Mark W.
[J]. MOLECULAR CANCER RESEARCH, 2014, 12 (08) : 1156 - 1165
[5] FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies
Cipriano, Rocky
Miskimen, Kristy L. S.
Bryson, Benjamin L.
Foy, Chase R.
Bartel, Courtney A.
Jackson, Mark W.
[J]. ONCOTARGET, 2013, 4 (05) : 729 - 738
[6] FAM83B mediates EGFR- and RAS-driven oncogenic transformation
Cipriano, Rocky
Graham, James
Miskimen, Kristy L. S.
Bryson, Benjamin L.
Bruntz, Ronald C.
Scott, Sarah A.
Brown, H. Alex
Stark, George R.
Jackson, Mark W.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (09) : 3197 - 3210
[7] Wnt/β-Catenin Signaling and Disease
Clevers, Hans
Nusse, Roel
[J]. CELL, 2012, 149 (06) : 1192 - 1205
[8] Kalogera E, 2017, GYNECOL ONCOL, V146, P187, DOI [10.1016/j., 10.1016/j.ygyno.2017.04.022]
[9] Kyrylkova Kateryna, 2012, Methods Mol Biol, V887, P41, DOI 10.1007/978-1-61779-860-3_5
[10] Knocking down FAM83B inhibits endometrial cancer cell proliferation and metastasis by silencing the PI3K/AKT/mTOR pathway
Lin, Qiongyan
Chen, Hui
Zhang, Minfen
Xiong, Hanzhen
Jiang, Qingping
[J]. BIOMEDICINE & PHARMACOTHERAPY, 2019, 115

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