Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques

被引：84

作者：

Vaz, Raquel ^{[1
]}

Hofmeister, Wolfgang ^{[2
,3
]}

Lindstrand, Anna ^{[4
]}

机构：

[1] Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

[2] Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Lab Mol & Cellular Cardiol, DK-5000 Odense, Denmark

[3] Univ Copenhagen, Novo Nordisk Fdn Stem Cell Biol Danstem, DK-2200 Copenhagen, Denmark

[4] Karolinska Univ Hosp, Karolinska Univ Lab, Ctr Mol Med & Clin Genet, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 06期

关键词：

zebrafish; neurodevelopmental disorders; disease models; functional assays; TARGETED GENE-EXPRESSION; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DANIO-RERIO; TRANSGENIC ZEBRAFISH; SEX-DIFFERENCES; OLFACTORY-BULB; SPINAL-CORD; NEURONS; MUTATIONS; BRAIN;

D O I：

10.3390/ijms20061296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For the past few years there has been an exponential increase in the use of animal models to confirm the pathogenicity of candidate disease-causing genetic variants found in patients. One such animal model is the zebrafish. Despite being a non-mammalian animal, the zebrafish model has proven its potential in recapitulating the phenotypes of many different human genetic disorders. This review will focus on recent advances in the modeling of neurodevelopmental disorders in zebrafish, covering aspects from early brain development to techniques used for modulating gene expression, as well as how to best characterize the resulting phenotypes. We also review other existing models of neurodevelopmental disorders, and the current efforts in developing and testing compounds with potential therapeutic value.

引用

页数：26

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