Botulinum toxin and the treatment of headache: A clinical review

被引：8
作者：
Finkel, Alan G. [1 ]
机构：
[1] Univ N Carolina, Carolina Headache Inst, Chapel Hill, NC USA
来源：
TOXICON | 2015年 / 107卷
关键词：
Onabotulinum toxin A; Headache; Migraine; Chronic migraine; Tension type headache; Treatment; TENSION-TYPE HEADACHE; DOUBLE-BLIND; TRIGEMINAL NEURALGIA; PROPHYLACTIC TREATMENT; OCCIPITAL NEURALGIA; MIGRAINE HEADACHES; CLUSTER HEADACHE; A INJECTION; PAIN; ONABOTULINUMTOXINA;
D O I：
10.1016/j.toxicon.2015.09.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since its discovery, Onabotulinum toxins have been tried for the treatment of various head, neck and face pain syndromes. The end result of controlled clinical trials was that there was not clear evidence for use in many of the common primary and secondary headaches. In chronic migraine, affecting 1-2% of the population, a fixed site and fixed dose treatment approach was shown to be superior to placebo and was approved for use. In this review, evidence for that use and the history leading to it is described. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：114 / 119
页数：6
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