Electrochemical C(sp3)-H Fluorination

被引：72

作者：

Takahira, Yusuke ^{[1
]}

Chen, Miao ^{[1
]}

Kawamata, Yu ^{[1
]}

Mykhailiuk, Pavel ^{[1
,2
,3
]}

Nakamura, Hugh ^{[1
]}

Peters, Byron K. ^{[1
]}

Reisberg, Solomon H. ^{[1
]}

Li, Chao ^{[1
]}

Chen, Longrui ^{[4
]}

Hoshikawa, Tamaki ^{[5
]}

Shibuguchi, Tomoyuki ^{[5
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

[2] Enamine Ltd, Chervonotkatska 78, UA-02094 Kiev, Ukraine

[3] Taras Shevchenko Natl Univ Kyiv, Chem Dept, Volodymyrska 64, UA-01601 Kiev, Ukraine

[4] Asymchem Life Sci Tianjin, Tianjin Econ Technol Dev Zone, Tianjin 300457, Peoples R China

[5] Eisai & Co Ltd, Discovery, Med Creat, Neurol Business Grp, 5-1-3 Tokodai, Tsukuba, Ibaraki 3002635, Japan

来源：

SYNLETT | 2019年 / 30卷 / 10期

基金：

瑞典研究理事会; 美国国家科学基金会;

关键词：

organic synthesis; electrochemistry; fluorination; C-H functionalization; radicals; C-H BONDS; OXIDATION; NITRATE;

D O I：

10.1055/s-0037-1611737

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C-H bonds are converted into their C-F congeners. The scalability of the reaction is also demonstrated with a 100 gram preparation of fluorovaline.

引用

页码：1178 / 1182

页数：5

共 30 条

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