hKv1.5 channels play a pivotal role in the functions of human alveolar macrophages

被引：18

作者：

Park, Seon-Ah

Lee, Yong-Chul

Ma, Tian-Ze

Park, Jeong-Ah

Han, Myung-Kwan

Lee, Hwang-Ho

Kim, Hwan-Gyu

Kwak, Yong-Geun ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Dept Pharmacol, Sch Med, Jeonju 561180, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Dept Internal Med, Sch Med, Jeonju 561180, Jeonbuk, South Korea

[3] Chonbuk Natl Univ, Dept Microbiol, Sch Med, Jeonju 561180, Jeonbuk, South Korea

[4] Chonbuk Natl Univ, Div Biol Sci, Jeonju 561756, Jeonbuk, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 346卷 / 02期

关键词：

hKv1.5; human alveolar macrophage; phagocytosis; migration;

D O I：

10.1016/j.bbrc.2006.05.149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the pharmacological properties, the molecular identity, and the functional roles of hKv1.5 channel in human alveolar macrophage. Some of outward K+ current was inhibited by 4-aminopyridine and antisense oligodeoxynucleotides against hKv1.5 mRNA. Consistently, the protein and mRNA expressions of hKv1.5 channel were detected. Furthermore, the phagocytosis and migration of human alveolar macrophages were significantly suppressed when the protein expression of hKv1.5 channel was lowered by the antisense hKv1.5 oligodeoxynucleotides. These results suggest that hKv1.5 channel is expressed in human alveolar macrophages and it plays a role in phagocytosis and migration of the human alveolar macrophage. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：567 / 571

页数：5

共 24 条

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