Self-assembly of a thymine quartet and quadruplex via an organic template

被引：4

作者：

Hui, Wei-Qiang Benjamin ^{[1
]}

Sherman, John C. ^{[1
]}

机构：

[1] Univ British Columbia, Vancouver, BC V6T 1Z1, Canada

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Cavitands; Supramolecular chemistry; Template synthesis; Thymine quartet; Thymine quadruplex; MAGNETIC-RESONANCE; BASE-STACKING; RNA TETRAPLEX; IMINO PROTON; DNA; TELOMERE; TARGETS; TETRADS; GUANINE; COMPLEXATION;

D O I：

10.1016/j.tetlet.2014.01.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two hydrophobic cavitands bearing four (1) and eight (2) thymidine residues covalently linked with triazole moieties is reported. Spectral evidence indicates the adoption of a hydrogen-bonded T-quartet assembly by 1 in chloroform at low temperature and a pi-stacked quadruplex by 2 in DMSO under ambient conditions. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1479 / 1485

页数：7

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