Effect of MgSO4, L-DOPA, and haloperidol on delayed stereotyped behavior caused by hyperactivation of the sensorimotor cortex in rats

被引：0

作者：

Lutsenko, VK ^{[1
]}

Khlebnikova, NN ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 09期

关键词：

cortical seizure activity; excitotoxicity; NMDA receptors; delayed behavioral stereotypy;

D O I：

10.1007/BF02438083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Repeated rhythmical electrostimulation of the right sensorimotor cortex resulted in persistent psychoaffective disorders and locomotor stereotypy in rats. Intraperitoneal or intrastriatal administration of MgSO4 did not prevent stereotyped behavior. The animals with developed syndrome exhibited sharply enhanced behavioral responses to L-DOPA and weakened cataleptic reactions to haloperidol and showed psychoaffective disorders in response to MgSO4 administration. It is suggested that dopaminergic hyperactivity and NMDA glutamate receptors are involved in the realization of delayed stereotyped behavior.

引用

页码：913 / 916

页数：4

共 18 条

[1]

[Anonymous], 1979, A Stereotaxic Atlas of the Rat Brain

[2] PREDICTORS FOR IMPROVEMENT AFTER ELECTROCONVULSIVE-THERAPY IN PARKINSONIAN-PATIENTS WITH ON-OFF SYMPTOMS [J].

BALLDIN, J ;

GRANERUS, AK ;

LINDSTEDT, G ;

MODIGH, K ;

WALINDER, J .

JOURNAL OF NEURAL TRANSMISSION, 1981, 52 (03) :199-211

[3] QUINOLINIC ACID LESIONS OF RAT STRIATUM ABOLISH D1-DOPAMINE AND D2-DOPAMINE RECEPTOR-MEDIATED CATALEPSY [J].

CALDERON, SF ;

SANBERG, PR ;

NORMAN, AB .

BRAIN RESEARCH, 1988, 450 (1-2) :403-407

[4] INTERACTIONS BETWEEN GLUTAMATERGIC AND MONOAMINERGIC SYSTEMS WITHIN THE BASAL GANGLIA - IMPLICATIONS FOR SCHIZOPHRENIA AND PARKINSONS-DISEASE [J].

CARLSSON, M ;

CARLSSON, A .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :272-276

[5] EXCITOTOXIC INJURY OF THE NEOSTRIATUM - A MODEL FOR HUNTINGTONS-DISEASE [J].

DIFIGLIA, M .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :286-289

[6] PHARMACOLOGY OF THE CORTICOCAUDATE EXCITATORY POSTSYNAPTIC POTENTIAL IN THE CAT - EVIDENCE FOR ITS MEDIATION BY QUISQUALATE-RECEPTORS OR KAINATE-RECEPTORS [J].

HERRLING, PL .

NEUROSCIENCE, 1985, 14 (02) :417-426

[7] KETAMINE-INDUCED HYPERLOCOMOTION ASSOCIATED WITH ALTERATION OF PRESYNAPTIC COMPONENTS OF DOPAMINE NEURONS IN THE NUCLEUS-ACCUMBENS OF MICE [J].

IRIFUNE, M ;

SHIMIZU, T ;

NOMOTO, M .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 40 (02) :399-407

[8] CHOREIC MOVEMENT INDUCED BY UNILATERAL KAINATE LESION OF THE STRIATUM AND L-DOPA ADMINISTRATION IN MONKEY [J].

KANAZAWA, I ;

TANAKA, Y ;

CHO, F .

NEUROSCIENCE LETTERS, 1986, 71 (02) :241-246

[9]

KOEK W, 1989, J PHARMACOL EXP THER, V250, P1019

[10]

Kretschmer BD, 1996, J NEUROSCI, V16, P1561

← 1 2 →