Endogenous TLR ligands and autoimmunity

被引：100
作者：
Wagner, Hermann [1 ]
机构：
[1] Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany
来源：
ADVANCES IN IMMUNOLOGY, VOL 91 | 2006年 / 91卷
关键词：
D O I：
10.1016/S0065-2776(06)91004-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Based on an evolutionary conserved repertoire Toll-like-receptors (TLRs) donate specificity to innate immune cells. Therefore, TLRs are considered as paradigmatic for "self" versus "non-self" discrimination. This view, however, needs to be modified since TLR's also appear to recognise "endogeneous", that is host-derived ligands, examples being host-derived DNA and -RNA. Here I discuss physiological and pathophysiological consequences of endogeneous ligand-recognition by TLRs. I conclude that endogeneous ligand recognition by TLRs drives sterile inflammation sustained by innate immune cells in certain autoimmune disorders.
引用
收藏
页码：159 / 173
页数：15
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