IL-33 contributes to disease severity in Psoriasis-like models of mouse

被引：33

作者：

Duan, Yaju ^{[1
]}

Dong, Yonghua ^{[1
]}

Hu, Hua ^{[1
]}

Wang, Qiumei ^{[2
]}

Guo, Sheng ^{[3
,4
]}

Fu, Dandan ^{[1
]}

Song, Xiangfeng ^{[3
,4
]}

Kalvakolanu, Dhan V. ^{[5
]}

Tian, Zhongwei ^{[1
]}

机构：

[1] Xinxiang Med Univ, Affiliated Hosp 1, Dept Dermatol, 88 Jiankang Rd, Xinxiang 453000, Henan, Peoples R China

[2] Cent Hosp Xinxiang, Dept Dermatol, Xinxiang 453000, Henan, Peoples R China

[3] Xinxiang Med Univ, Sch Basic Med Sci, Inst Precis Med, Xinxiang 453000, Henan, Peoples R China

[4] Xinxiang Med Univ, Dept Immunol, Xinxiang 453000, Henan, Peoples R China

[5] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

CYTOKINE | 2019年 / 119卷

基金：

芬兰科学院;

关键词：

Interleukin-33; HaCaT cell; Autophagy; Psoriasis-like skin inflammation; STAT3; MAST-CELL; AUTOPHAGY; INTERLEUKIN-33; KERATINOCYTES; INFLAMMATION; MECHANISMS; EXPRESSION; ARTHRITIS; CYTOKINE; BECLIN;

D O I：

10.1016/j.cyto.2019.02.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune cells infiltrating the psoriatic skin secrete high amounts of pro-inflammatory cytokines IL-17, TNF-alpha, IL-21 and IL-36 resulting in chronic inflammation. However, the exact cellular and molecular mechanisms have not been fully understood. We report here elevation of IL-33 expression in psoriatic lesions. Studies in imiquimod (IMQ)-induced mice with psoriatic inflammation confirmed a critical role for IL-33 in driving the disease. IL-33 reduces the CD4(+) and CD8(+) cells, inhibits autophagy in IMQ-treated mouse skin, and promoted tyrosyl phosphorylation of STAT3. Thus, IL-33 appears to be a major risk factor for severity of psoriasis-like skin inflammation. Our findings may open new perspectives for understanding the mechanisms and developing a therapeutic strategy for psoriasis.

引用

页码：159 / 167

页数：9

共 31 条

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