Effects of Intra-aortic Balloon Pump Counterpulsation on Left Ventricular Mechanoenergetics in a Porcine Model of Acute Ischemic Heart Failure

被引：15
作者：
Malliaras, Konstantinos [1 ]
Charitos, Efstratios [1 ]
Diakos, Nikolaos [1 ]
Pozios, Iraklis [1 ]
Papalois, Apostolos [2 ]
Terrovitis, John [1 ]
Nanas, John [1 ]
机构：
[1] Univ Athens, Sch Med, Laiko Hosp, Dept Cardiol 3, GR-11527 Athens, Greece
[2] Elpen Pharmaceut, Expt Res Ctr, Athens, Greece
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2014年 / 7卷 / 09期
关键词：
Intra-aortic balloon pump; Counterpulsation; Mechanical circulatory support; Acute heart failure; Pressure-volume loops; CORONARY PERFUSION-PRESSURE; CARDIOGENIC-SHOCK; ISOVOLUMIC RELAXATION; MYOCARDIAL-INFARCTION; DIASTOLIC FUNCTION; CARDIAC-FUNCTION; LOAD; VOLUME; PERFORMANCE; ASSISTANCE;
D O I：
10.1007/s12265-014-9600-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effects of intra-aortic balloon pump (IABP) counterpulsation on left ventricular (LV) contractility, relaxation, and energy consumption and probed the underlying physiologic mechanisms in 12 farm pigs, using an ischemia-reperfusion model of acute heart failure. During both ischemia and reperfusion, IABP support unloaded the LV, decreased LV energy consumption (pressure-volume area, stroke work), and concurrently improved LV mechanical performance (ejection fraction, stroke volume, cardiac output). During reperfusion exclusively, IABP also improved LV relaxation (tau) and contractility (Emax, PRSW). The beneficial effects of IABP support on LV relaxation and contractility correlated with IABP-induced augmentation of coronary blood flow. In conclusion, we find that during both ischemia and reperfusion, IABP support optimizes LV energetic performance (decreases energy consumption and concurrently improves mechanical performance) by LV unloading. During reperfusion exclusively, IABP support also improves LV contractility and active relaxation, possibly due to a synergistic effect of unloading and augmentation of coronary blood flow.
引用
收藏
页码：810 / 820
页数：11
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