Osteosarcoma of the jaws: An overview of the pathophysiological mechanisms

被引：24

作者：

Bertin, Helios ^{[1
,2
]}

Gomez-Brouchet, A. ^{[3
]}

Redini, F. ^{[2
]}

机构：

[1] Nantes Univ Hosp, Dept Maxillofacial Surg, 1 Pl Alexis Ricordeau, F-44093 Nantes 1, France

[2] Nantes Med Sch, Bone Sarcoma & Remodeling Calcified Tisues PhyOs, UMR 1238, 1 Rue Gaston Veil, F-44035 Nantes, France

[3] Toulouse Univ Hosp, Dept Pathol, IUCT Oncopole, 1 Ave Irene Joliot Curie, F-31059 Toulouse 9, France

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 156卷

关键词：

Osteosarcoma; Mandible; Tumour environment; Immunity; Molecular biology; Vascularization; GROWTH-FACTOR EXPRESSION; IMMUNOHISTOCHEMICAL ANALYSIS; BONE MICROENVIRONMENT; GRADE OSTEOSARCOMAS; PROTEIN EXPRESSION; OSTEOGENIC-SARCOMA; MUTATION SPECTRUM; TUMOR; HEAD; MDM2;

D O I：

10.1016/j.critrevonc.2020.103126

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma (OS) is the most common cancer of bone. Jaw osteosarcoma (JOS) is rare and it differs from longbone OS (LBOS) in terms of the time of onset (two decades later), lower metastatic spread, and better survival. OS is characterized by the proliferation of osteoblastic precursor cells and the production of osteoid or immature bone. OS arises from a combination of genetic aberrations and a favourable microenvironment. This local microenvironment includes bone cells, blood vessels, stromal cells, and immune infiltrates, all of which may constitute potential targets for anti-cancer drugs. Differences in the clinical and biological behaviour of JOS versus LBOS are likely to at least in part be due to differences in the microenvironment between the two sites. The present review provides a brief overview of the known pathophysiological parameters involved in JOS.

引用

页数：9

共 108 条

[1] Bone microenvironment signals in osteosarcoma development [J].

Alfranca, Arantzazu ;

Martinez-Cruzado, Lucia ;

Tornin, Juan ;

Abarrategi, Ander ;

Amaral, Teresa ;

de Alava, Enrique ;

Menendez, Pablo ;

Garcia-Castro, Javier ;

Rodriguez, Rene .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (16) :3097-3113

[2] Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms [J].

Alvarez, Carla ;

Monasterio, Gustavo ;

Cavalla, Franco ;

Cordova, Luis A. ;

Hernandez, Marcela ;

Heymann, Dominique ;

Garlet, Gustavo P. ;

Sorsa, Timo ;

Parnanen, Pirjo ;

Lee, Hsi-Ming ;

Golub, Lorne M. ;

Vernal, Rolando ;

Kantarci, Alpdogan .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[3] Evaluation of tumor-infiltrating lymphocytes in osteosarcomas of the jaws: a multicenter study [J].

Alves, Pollianna Muniz ;

Almeida de Arruda, Jose Alcides ;

Costa Arantes, Diego Antonio ;

Santos Costa, Sara Ferreira ;

Souza, Lucas Lacerda ;

Rebelo Pontes, Helder Antonio ;

Fonseca, Felipe Paiva ;

Mesquita, Ricardo Alves ;

Weege Nonaka, Cassiano Francisco ;

Mendonca, Elismauro Francisco ;

Batista, Aline Carvalho .

VIRCHOWS ARCHIV, 2019, 474 (02) :201-207

[4] p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases [J].

Asioli, Sofia ;

Righi, Alberto ;

Rucci, Paola ;

Tarsitano, Achille ;

Marchetti, Claudio ;

Bacchini, Patrizia ;

Balbi, Tiziana ;

Bertoni, Franco ;

Foschini, Maria Pia .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2017, 39 (09) :1825-1831

[5]

Baumhoer Daniel, 2017, Surg Pathol Clin, V10, P693, DOI 10.1016/j.path.2017.04.007

[6] Osteosarcomas of the jaws differ from their peripheral counterparts and require a distinct treatment approach. Experiences from the DOESAK Registry [J].

Baumhoer, Daniel ;

Brunner, Philippe ;

Eppenberger-Castori, Serenella ;

Smida, Jan ;

Nathrath, Michaela ;

Jundt, Gernot .

ORAL ONCOLOGY, 2014, 50 (02) :147-153

[7] The RANKL-OPG system in clinical periodontology [J].

Belibasakis, Georgios N. ;

Bostanci, Nagihan .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2012, 39 (03) :239-248

[8] Jaw osteosarcoma models in mice: first description [J].

Bertin, Helios ;

Guilho, Romain ;

Brion, Regis ;

Amiaud, Jerome ;

Battaglia, Severine ;

Moreau, Anne ;

Brouchet-Gomez, Anne ;

Longis, Julie ;

Piot, Benoit ;

Heymann, Dominique ;

Corre, Pierre ;

Redini, Francoise .

JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (1)

[9] Establishment of a patient-derived orthotopic osteosarcoma mouse model [J].

Blattmann, Claudia ;

Thiemann, Markus ;

Stenzinger, Albrecht ;

Roth, Eva K. ;

Dittmar, Anne ;

Witt, Hendrik ;

Lehner, Burkhard ;

Renker, Eva ;

Jugold, Manfred ;

Eichwald, Viktoria ;

Weichert, Wilko ;

Huber, Peter E. ;

Kulozik, Andreas E. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13

[10] Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults [J].

Boon, Eline ;

van der Graaf, Winette T. A. ;

Gelderblom, Hans ;

Tesselaar, Margot E. T. ;

van Es, Robert J. J. ;

Oosting, Sjoukje F. ;

de Bree, Remco ;

van Meerten, Esther ;

Hoeben, Ann ;

Smeele, Ludi E. ;

Willems, Stefan M. ;

Witjes, Max J. H. ;

Buter, Jan ;

de Jong, Robert J. Baatenburg ;

Flucke, Uta E. ;

Peer, Petronella G. M. ;

Bovee, Judith V. M. G. ;

Van Herpen, Carla M. L. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2017, 39 (01) :140-146

← 1 2 3 4 5 6 7 8 9 10 →