Volume matters: Breast induration is associated with irradiated breast volume in the Danish Breast Cancer Group phase III randomized Partial Breast Irradiation trial

被引：26

作者：

Thomsen, Mette S. ^{[1
]}

Alsner, Jan ^{[2
]}

Nielsen, Hanne M. ^{[3
]}

Jakobsen, Erik H. ^{[4
]}

Nielsen, Mette H. ^{[5
]}

Moller, Mette ^{[6
]}

Pedersen, Anders N. ^{[7
]}

Yates, Esben ^{[1
]}

Berg, Martin ^{[8
]}

Lorenzen, Ebbe ^{[9
]}

Jensen, Ingelise ^{[10
]}

Josipovic, Mirjana ^{[7
]}

Overgaard, Jens ^{[2
]}

Offersen, Birgitte V. ^{[2
,3
]}

机构：

[1] Aarhus Univ Hosp, Dept Med Phys, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[2] Aarhus Univ Hosp, Dept Expt Clin Oncol, Aarhus, Denmark

[3] Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark

[4] Lillebaelt Hosp, Dept Oncol, Vejle, Denmark

[5] Odense Univ Hosp, Dept Oncol, Odense, Denmark

[6] Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark

[7] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, Copenhagen, Denmark

[8] Lillebaelt Hosp, Dept Med Phys, Vejle, Denmark

[9] Odense Univ Hosp, Lab Radiat Phys, Odense, Denmark

[10] Aalborg Univ Hosp, Dept Med Phys, Aalborg, Denmark

来源：

RADIOTHERAPY AND ONCOLOGY | 2022年 / 177卷

关键词：

Partial breast irradiation; Dose volume relationship; Randomised trial; Quality; Assurance; NORMAL TISSUE COMPLICATIONS; IN-SITU CARCINOMA; CONSERVING SURGERY; RADIATION-THERAPY; FEMALE BREAST; RADIOTHERAPY; RISK; BOOST; BRACHYTHERAPY; DELINEATION;

D O I：

10.1016/j.radonc.2022.09.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The relation between breast induration grade 2-3 at 3 years after radiation therapy and irradiated breast volume was investigated for patients in the Danish Breast Cancer Group (DBCG) Partial Breast Irradiation (PBI) trial.METHODS Treatment plan data was obtained from the Danish radiotherapy plan database. Dosimetric parameters for breast and organs at risk were determined. Breast induration data was obtained from the DBCG database. The volume of the whole breast (CTVp_breast) treated to various dose levels was determined for treatment plans in both arms. Logistic regression was used to assess the frequency of induration on breast volume irradiated to >= 40 Gy. RESULTS PBI and WBI was given to 433 and 432 patients, respectively. Median and interquartile ranges (IQR) for CTVp_breast were 710 mL (467- 963 mL; PBI) and 666 mL (443-1012 mL; WBI) (p = 0.98). Median and IQR for CTVp_breast treated to >= 40 Gy was 24.9% (18.6-32.6%; PBI) and 59.8% (53.6-68.5%; WBI). Grade 2-3 induration was observed in 5% (PBI) and 10% (WBI) of the patients. A dose-response relationship was established between irradiated breast volume and frequency of breast induration. From the model, 5% and 10% risks of breast induration were observed for >= 40 Gy delivered to CTVp_breast volumes of 177 mL (95%CI, 94- 260 mL) and 426 mL (95%CI, 286-567 mL), respectively. CONCLUSION The frequency of breast induration increased significantly with increasing irradiated breast volume, strongly favouring small volumes and PBI. Thus, treated breast volume - not the breast size itself - is the risk factor for induration. This is the first report directly linking the 40 Gy irradiated breast volume to breast induration.(c) 2022 The Authors. Published by Elsevier B.V. Radiotherapy and Oncology 177 (2022) 231-235 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：231 / 235

页数：5

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