Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole

被引：5

作者：

Bentley, JM ^{[1
]}

Davidson, JE ^{[1
]}

Duncton, MAJ ^{[1
]}

Giles, PR ^{[1
]}

Pratt, RM ^{[1
]}

机构：

[1] Vernalis Res Ltd, Dept Chem, Wokingham, England

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 12期

关键词：

indole; Ro; 60-0175; Lemgruber-Batcho; 5-HT2C receptor;

D O I：

10.1081/SCC-120038513

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the target indole.

引用

页码：2295 / 2300

页数：6

共 6 条

[1] Preparation of 6-chloro-5-fluoroindole via the use of palladium and copper-mediated heterocyclisations [J].