β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)-H bonds using a palladium catalyst

被引：80

作者：

Peng, Jing ^{[1
]}

Chen, Chao ^{[1
]}

Xi, Chanjuan ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; ONE-POT SYNTHESIS; REDUCTIVE ELIMINATION; HYDROGEN ELIMINATION; HYDRIDE ELIMINATION; COUPLING REACTIONS; PIVALIC ACID; METAL-FREE; FUNCTIONALIZATION; COMPLEXES;

D O I：

10.1039/c5sc03903g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method of selective beta-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp(3))-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp(3))-C(sp(2)) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp(3))-H functionalization.

引用

页码：1383 / 1387

页数：5

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