fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate

被引：10

作者：

Varfolomeev, Sergey D. ^{[1
]}

Semenova, Nataliya A. ^{[1
]}

Ublinskiy, Maxim, V ^{[1
]}

Bykov, Valeriy, I ^{[1
]}

Tsybenova, Svetlana B. ^{[1
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Ul Kosygina 4, Moscow 119334, Russia

来源：

CHEMICAL PHYSICS LETTERS | 2019年 / 729卷

基金：

俄罗斯科学基金会;

关键词：

fMRI; MR-spectroscopy; BOLD-signal; Glutamate; N-acetylaspartate; Canavan disease; Kinetic model; Steady state; Inhibition; Trigger; Autostabilization; BLOOD-FLOW; BRAIN; ASPARTOACYLASE; ASPARTATE; STIMULATION; METABOLISM; MECHANISMS; GLUTAMATE; CORTEX;

D O I：

10.1016/j.cplett.2019.05.033

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A kinetic model of the process response of nervous tissue to an external signal stimulus is proposed. The model is based on the multistage and non-linear nature of the dynamic process of changes of N-acetylaspartate concentration. The existence of multiple steady states explains the trigger effect of the system. The effect of substrate inhibition for this system was studied as a necessary factor of N-acetylaspartate's autostabilization as a key metabolite in the brain. The appearance of N-acetylaspartate's "anti-peak" causes a wave of its hydrolysis products, such as aspartic acid and acetic acid.

引用

页码：84 / 91

页数：8

共 31 条

[21] BRAIN MAGNETIC-RESONANCE-IMAGING WITH CONTRAST DEPENDENT ON BLOOD OXYGENATION [J].

OGAWA, S ;

LEE, TM ;

KAY, AR ;

TANK, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9868-9872

[22]

Parizel PM, 2010, CLINICAL MR IMAGING: A PRACTICAL APPROACH, THIRD EDITION, P107, DOI 10.1007/978-3-540-74504-4_2

[23] Functional 1H-MRS findings in migraine patients with and without aura assessed interictally [J].

Sarchielli, P ;

Tarducci, R ;

Presciutti, O ;

Gobbi, G ;

Pelliccioli, GP ;

Stipa, G ;

Alberti, A ;

Capocchi, G .

NEUROIMAGE, 2005, 24 (04) :1025-1031

[24]

Schousboe A., 2016, GLUTAMATE GABA GLUTA

[25] Metabolic Dysfunction and Relationship in Human Frontoparietal Cortex in Severe Traumatic Brain Injury: Single-Voxel 1H Magnetic Resonance Spectroscopy Study [J].

Semenova, N. A. ;

Akhadov, T. A. ;

Petryaykin, A. V. ;

Sidorin, S. S. ;

Lukovenkov, A. V. ;

Varfolomeev, S. D. .

BIOCHEMISTRY-MOSCOW, 2012, 77 (04) :388-394

[26]

Stagg C., 2014, Magnetic resonance spectroscopy. Tools for neuroscience research and emerging clinical applications

[27] Relaxation kinetics in the study of neurobiological processes using functional magnetic resonance imaging and spectroscopy [J].

Ublinskii, M. V. ;

Semenova, N. A. ;

Akhadov, T. A. ;

Mel'nikov, I. A. ;

Varfolomeev, S. D. .

RUSSIAN CHEMICAL BULLETIN, 2015, 64 (02) :451-457

[28] Supercomputer technologies for structural-kinetic study of mechanisms of enzyme catalysis: A quantum-chemical description of aspartoacylase catalysis [J].

Varfolomeev, S. D. ;

Kots, E. D. ;

Khrenova, M. G. ;

Lushchekina, S. V. ;

Nemukhin, A. V. .

DOKLADY PHYSICAL CHEMISTRY, 2017, 474 :89-92

[29]

Varfolomeev S. D., 1999, BIOKINETICS

[30] Relationship between enzyme properties and disease progression in Canavan disease [J].

Zano, Stephen ;

Wijayasinghe, Yasanandana S. ;

Malik, Radhika ;

Smith, Joshua ;

Viola, Ronald E. .

JOURNAL OF INHERITED METABOLIC DISEASE, 2013, 36 (01) :1-6

← 1 2 3 4 →