fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate

被引：10

作者：

Varfolomeev, Sergey D. ^{[1
]}

Semenova, Nataliya A. ^{[1
]}

Ublinskiy, Maxim, V ^{[1
]}

Bykov, Valeriy, I ^{[1
]}

Tsybenova, Svetlana B. ^{[1
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Ul Kosygina 4, Moscow 119334, Russia

来源：

CHEMICAL PHYSICS LETTERS | 2019年 / 729卷

基金：

俄罗斯科学基金会;

关键词：

fMRI; MR-spectroscopy; BOLD-signal; Glutamate; N-acetylaspartate; Canavan disease; Kinetic model; Steady state; Inhibition; Trigger; Autostabilization; BLOOD-FLOW; BRAIN; ASPARTOACYLASE; ASPARTATE; STIMULATION; METABOLISM; MECHANISMS; GLUTAMATE; CORTEX;

D O I：

10.1016/j.cplett.2019.05.033

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A kinetic model of the process response of nervous tissue to an external signal stimulus is proposed. The model is based on the multistage and non-linear nature of the dynamic process of changes of N-acetylaspartate concentration. The existence of multiple steady states explains the trigger effect of the system. The effect of substrate inhibition for this system was studied as a necessary factor of N-acetylaspartate's autostabilization as a key metabolite in the brain. The appearance of N-acetylaspartate's "anti-peak" causes a wave of its hydrolysis products, such as aspartic acid and acetic acid.

引用

页码：84 / 91

页数：8

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