Bioactive steroidal alkaloids from Solanum umbelliferum

被引：34
|
作者：
Kim, YC [1 ]
Che, QM [1 ]
Gunatilaka, AAL [1 ]
Kingston, DGI [1 ]
机构：
[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061
来源：
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期
关键词：
D O I：
10.1021/np960125a
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.
引用
收藏
页码：283 / 285
页数：3
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