Bioactive steroidal alkaloids from Solanum umbelliferum

被引：34

作者：

Kim, YC ^{[1
]}

Che, QM ^{[1
]}

Gunatilaka, AAL ^{[1
]}

Kingston, DGI ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np960125a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D-glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.

引用

页码：283 / 285

页数：3

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