Immune modulation by virus-encoded secreted chemokine binding proteins

被引:35
|
作者
Heidarieh, Haleh [1 ]
Hernaez, Bruno [1 ]
Alcami, Antonio [1 ]
机构
[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Consejo Super Invest Cient, E-28049 Madrid, Spain
关键词
Chemokines; Chemokine binding proteins; Poxviruses; Herpesviruses; Immune evasion; Glycosaminoglycans; NECROSIS-FACTOR RECEPTOR; INTERFERON-GAMMA RECEPTOR; GLYCOPROTEIN-G GG; CC-CHEMOKINE; VACCINIA VIRUS; MYXOMA VIRUS; DECOY RECEPTOR; ORF VIRUS; COWPOX VIRUS; IN-VITRO;
D O I
10.1016/j.virusres.2015.02.028
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode soluble chemokine binding proteins that bind chemokines with high affinity, even though they do not show sequence similarity to cellular chemokine receptors. This review summarizes the different secreted viral chemokine binding proteins described to date, with special emphasis on the diverse mechanisms of action they exhibit to interfere with chemokine function and their specific contribution to virus pathogenesis. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:67 / 75
页数:9
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