Surfactant proteins-A and -B are elevated in plasma of patients with acute respiratory failure

被引:106
作者
Doyle, IR
Bersten, AD
Nicholas, TE
机构
[1] FLINDERS MED CTR, SCH MED, DEPT HUMAN PHYSIOL, ADELAIDE, SA, AUSTRALIA
[2] FLINDERS MED CTR, SCH MED, DEPT CRIT CARE MED, ADELAIDE, SA, AUSTRALIA
关键词
D O I
10.1164/ajrccm.156.4.9603061
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Surfactant protein-A (SP-A) leaks into the circulation of patients with acute respiratory distress syndrome (ARDS) or acute cardiogenic pulmonary edema (APE) in a manner inversely related to lung function. Since surfactant protein-B (SP-B) is synthesized as a precursor considerably smaller than alveolar SP-A, we investigated whether it enters the circulation more readily. Reactivities consistent with SP-B proprotein (similar to 42 to similar to 45 kD) and the similar to 25 kD processing intermediate were detected in plasma. Plasma immunoreactive SP-B levels were significantly higher in ARDS (8,007 +/- 1,654 ng/ml [mean +/- SEM], n = 22) and APE (3,646 +/- 635 ng/ml, n = 10) patients compared with normal subjects (1,685 +/- 58 ng/ml, n = 33) and ventilated patients with no cardiorespiratory disease (1,829 +/- 184 ng/ml, n = 7). All groups had plasma SP-B/SP-A ratios similar to 6- to similar to 8 fold higher than in normal lavage or ARDS tracheal aspirate fluid, consistent with protein sieving. During admission, both plasma SP-B and the SP-B/SP-A ratio were inversely related to blood oxygenation (Pa-O2/Fl(O2)) (p < 0.0001 and p < 0.025, n = 260 from 39 patients; Spearman) and static respiratory system compliance (Delta V/Delta P) (p < 0.0001 and p < 0.01, n = 168 from 25 patients). We describe in detail three patients and con elude that immunoreactive SP-B enters more readily than SP-A, is cleared acutely, and provides a better indicator of lung trauma.
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页码:1217 / 1229
页数:13
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