Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes

被引：58

作者：

Mokhlesi, Babak ^{[1
]}

Temple, Karla A. ^{[1
]}

Tjaden, Ashley H. ^{[2
]}

Edelstein, Sharon L. ^{[2
]}

Utzschneider, Kristina M. ^{[3
,4
]}

Nadeau, Kristen J. ^{[5
]}

Hannon, Tamara S. ^{[6
]}

Sam, Susan ^{[1
]}

Barengolts, Elena ^{[7
]}

Manchanda, Shalini ^{[6
]}

Ehrmann, David A. ^{[1
]}

Van Cauter, Eve ^{[1
]}

机构：

[1] Univ Chicago, Chicago, IL 60637 USA

[2] George Washington Univ, Ctr Biostat, RISE Coordinating Ctr, Rockville, MD USA

[3] VA Puget Sound Hlth Care Syst, Seattle, WA USA

[4] Univ Washington, Seattle, WA 98195 USA

[5] Univ Colorado, Childrens Hosp Colorado, Anschutz Med Campus, Denver, CO 80202 USA

[6] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[7] Jesse Brown VA Med Ctr, Chicago, IL USA

来源：

DIABETES CARE | 2019年 / 42卷 / 07期

基金：

美国国家卫生研究院;

关键词：

IMPAIRED FASTING GLUCOSE; SOCIAL JETLAG; GENERAL-POPULATION; SHIFT WORK; DURATION; RISK; QUALITY; RESTRICTION; DISTURBANCES; METAANALYSIS;

D O I：

10.2337/dc19-0298

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Sleep disturbances and circadian misalignment (social jet lag, late chronotype, or shift work) have been associated with worse glycemic control in type 2 diabetes (T2D). Whether these findings apply to adults with prediabetes is yet unexplored. We hypothesized that self-reported short sleep, poor sleep quality, and/or circadian misalignment are associated with higher glycemia, BMI, and blood pressure (BP) in adults with prediabetes or recently diagnosed, untreated T2D. RESEARCH DESIGN AND METHODS Our cohort included 962 overweight/obese adults ages 20-65 years with prediabetes or recently diagnosed, untreated T2D who completed a 2-h oral glucose tolerance test and validated sleep questionnaires. Independent associations of sleep and circadian variables with glycemia, BMI, and BP were evaluated with regression models. RESULTS The multiethnic cohort was 55% men, with mean +/- SD age 52.2 +/- 9.5 years and BMI 34.7 +/- 5.5 kg/m(2). Mean sleep duration was 6.6 +/- 1.3 h. Poor sleep quality was reported by 54% and high risk for obstructive sleep apnea by 64%. HbA(1c) was significantly higher in those reporting 8 h sleep per night. Sleep duration >8 h was also associated with higher fasting glucose and CONCLUSIONS In our cohort, self-reported short and long sleep were both associated with adverse measures of glycemia, and short sleep and shift work were associated with higher BMI. Further research using objective measures of sleep is needed to better delineate the relationship between sleep and glycemia in adults with prediabetes or T2D.

引用

页码：1326 / 1332

页数：7