ω-3 Fatty Acid Intakes Are Inversely Related to Elevated Depressive Symptoms among United States Women

被引:44
作者
Beydoun, May A. [1 ]
Kuczmarski, Marie T. Fanelli [2 ]
Beydoun, Hind A. [3 ]
Hibbeln, Joseph R. [4 ]
Evans, Michele K. [1 ]
Zonderman, Alan B. [1 ]
机构
[1] NIA, Intramural Res Program, Baltimore, MD 21224 USA
[2] Univ Delaware, Dept Behav Hlth & Nutr, Newark, DE USA
[3] Eastern Virginia Med Sch, Grad Program Publ Hlth, Norfolk, VA 23501 USA
[4] NIAAA, Nutr Neurosci Sect, Intramural Res Program, NIH, Bethesda, MD USA
关键词
MULTIPLE-PASS METHOD; POLYUNSATURATED FATTY-ACIDS; VITAMIN-E LEVELS; FISH CONSUMPTION; MAJOR DEPRESSION; DIETARY-INTAKE; FOLLOW-UP; ATHEROSCLEROSIS RISK; COGNITIVE DECLINE; PLASMA FOLATE;
D O I
10.3945/jn.113.179119
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Evidence that depressive symptoms are inversely related to n-3 (w-3) fatty acids is growing among United States adults. We assessed whether self-reported depressive symptoms were inversely associated with n-3 fatty acid intakes by using a cross-sectional study in 1746 adults (aged 30-65 y) in Baltimore City, MD (2004-2009). The 20-item Center for Epidemiologic Studies-Depression Scale (CES-D) was used, with a CES-D score >= 16 suggestive of elevated depressive symptoms (EDS). By using the mean of two 24-h dietary recalls, n-3 highly unsaturated fatty acids (HUFAs; carbons), n-3 polyunsaturated fatty acids (PUFAs; >= 18 carbons), and plausible ratios with n-6 (omega 6) fatty acids were estimated. EDS prevalence was 18.1% among men and 25.6% among women. In women, the uppermost tertile (tertile 3) of n-3 PUFAs (compared with tertile 1) was associated with reduced odds of EDS by 49%, with a substantial sex differential. The n-3 PUFA:n-6:PUFA ratio was inversely related to EDS among women (tertile 2 vs. tertile 1, OR: 0.74; 95% CI: 0.41, 1.32; tertile 3 vs. tertile 1, OR: 0.47; 95% Cl: 0.27, 0.83). A similar pattern was noted for n-3 HUFA:n-6 HUFA among women. For CES-D subscales, n-3 PUFA 1% of energy) was inversely related to somatic complaints, whereas positive affect was directly related to n-3 HUFA (% of energy; total population and among women), n-3 HUFA:n-6 HUFA (women), and n-3 HUFA:n-6 PUFA (total population and among women). In sum, among United States women, higher intakes of n-3 fatty acids [absolute (n-3) and relative to n-6 fatty acids (n-3:n-6)) were associated with lower risk of elevated depressive symptoms, specifically in domains of somatic complaints (mainly n-3 PUFAs) and positive affect (mainly n-3 HUFAs).
引用
收藏
页码:1743 / 1752
页数:10
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