Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells

被引：89
|
作者：
McNulty, James [1 ]
Nair, Jerald J. [1 ]
Bastida, Jaume [2 ]
Pandey, Siyaram [3 ]
Griffin, Carly [3 ]
机构：
[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada
[2] Univ Barcelona, Fac Farm, Dept Nat Prod, E-08028 Barcelona, Spain
[3] Univ Windsor, Dept Chem & Biochem, Windsor, ON N9B 3P4, Canada
来源：
PHYTOCHEMISTRY | 2009年 / 70卷 / 07期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Narcissus bujei; Amaryllidaceae; Lycorine; Apoptosis-induction; Anticancer agent; Alkaloid; AMARYLLIDACEAE ALKALOIDS; ANTIMALARIAL ALKALOIDS; BIOLOGICAL EVALUATION; PANCRATISTATIN; INHIBITORS; IDENTIFICATION; NARCICLASINE; REPLICATION; REFINEMENT; PLANTS;
D O I：
10.1016/j.phytochem.2009.04.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and their apoptosis-inducing activity investigated in human leukemia (Jurkat) cells. Further insights into the nature of this interesting apoptosis-inducing pharmacophore are described, including the requirement of both free hydroxyl groups in ring-C. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：913 / 919
页数：7
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