Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential

被引：40

作者：

Whitehead, Michael ^{[1
,2
]}

Osborne, Andrew ^{[1
,2
]}

Widdowson, Peter S. ^{[3
,4
]}

Yu-Wai-Man, Patrick ^{[1
,2
,5
,6
,7
,8
]}

Martin, Keith R. ^{[1
,2
,6
,9
,10
,11
]}

机构：

[1] Van Geest Bldg,West Forvie Site, Cambridge CB2 0PY, England

[2] Univ Cambridge, Dept Clin Neurosci, Cambridge Ctr Brain Repair, Cambridge, England

[3] Camburgh House 27 New Dover Rd, Canterbury CT1 3DN, Kent, England

[4] Ikarovec Ltd, Canterbury, Kent, England

[5] Univ Cambridge, Dept Clin Neurosci, MRC Mitochondrial Biol Unit, Cambridge, England

[6] Cambridge Univ Hosp, Addenbrookes Hosp, Cambridge Eye Unit, Cambridge, England

[7] Moorfields Eye Hosp, NIHR Biomed Res Ctr, London, England

[8] UCL Inst Ophthalmol, London, England

[9] Univ Cambridge, Wellcome Trust MRC Cambridge Stem Cell Inst, Cambridge, England

[10] Ctr Eye Res Australia, Melbourne, Vic, Australia

[11] Univ Melbourne, Melbourne, Vic, Australia

来源：

JOURNAL OF DIABETES RESEARCH | 2019年 / 2019卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; MACULAR EDEMA; TIE2; CELL; ANGIOGENESIS; MODEL; NEOVASCULARIZATION; COMPLICATIONS; PERMEABILITY; RECRUITMENT;

D O I：

10.1155/2019/5140521

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated. Recently, a role for angiopoietin (Ang) proteins in the pathophysiology of DR has been proposed by several research groups, and several aspects of Ang signalling are being explored as novel therapeutic strategies. Here, we review the role of the Ang proteins in two important forms of DR, diabetic macular oedema and proliferative diabetic retinopathy. The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR.

引用

页数：9

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