Human pluripotent stem cell based islet models for diabetes research

被引：21
作者：
Balboa, Diego [1 ]
Otonkoski, Timo [1 ,2 ,3 ]
机构：
[1] Univ Helsinki, Res Programs Unit, Mol Neurol & Biomedicum Stem Cell Ctr, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Childrens Hosp, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 29卷 / 06期
基金：
芬兰科学院;
关键词：
diabetes models; pancreas development; beta cell physiology; human pluripotent stem cells; disease modeling; induced pluripotent stem cells; genome editing; INSULIN-PRODUCING CELLS; PANCREATIC BETA-CELLS; EFFICIENT DIFFERENTIATION; DEFINITIVE ENDODERM; BASEMENT-MEMBRANE; GENE-EXPRESSION; MOUSE; TRANSCRIPTION; GENERATION; MATURATION;
D O I：
10.1016/j.beem.2015.10.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although similar, mouse and human pancreatic development and beta cell physiology have significant differences. For this reason, mouse models present shortcomings that can obscure the understanding of human diabetes pathology. Progress in the field of human pluripotent stem cell (hPSC) differentiation now makes it possible to derive unlimited numbers of human beta cells in vitro. This constitutes an invaluable approach to gain insight into human beta cell development and physiology and to generate improved disease models. Here we summarize the main differences in terms of development and physiology of the pancreatic endocrine cells between mouse and human, and describe the recent progress in modeling diabetes using hPSC. We highlight the need of developing more physiological hPSC-derived beta cell models and anticipate the future prospects of these approaches. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：899 / 909
页数：11
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