Hepatotoxicity by Drugs: The Most Common Implicated Agents

被引：189

作者：

Bjornsson, Einar S. ^{[1
,2
]}

机构：

[1] Univ Iceland, Natl Univ Hosp Iceland, Div Gastroenterol & Hepatol, Dept Internal Med, IS-108 Reykjavik, Iceland

[2] Univ Iceland, Fac Med, IS-108 Reykjavik, Iceland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 02期

关键词：

hepatotoxicity; drugs; drug-induced liver injury; idiosyncratic; INDUCED LIVER-INJURY; POPULATION; OUTCOMES; HEPATITIS; FEATURES;

D O I：

10.3390/ijms17020224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.

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