Preparation of Poly ( L-lactic acid )/Mesoporous Silica Nanoparticles Composite Nanofibers via Electrospinning

Organic/inorganic materials have received growing attention lately due to the combination of their excellent properties. In this study, mesoporous silica nanoparticles (MSNs) were successfully prepared by surfactant-tempting method and used as carriers for loading Doxorubicin Hydrochloride (DOX), the prepared MSNs were then encapsulated into Poly (L-lactic acid) (PLLA) nanofibers via electrospinning. These PLLA/MSNs composite nanofibers containing different MSNs contents, a novel drug delivery system, were therefore successfully prepared. The results indicate that the surface morphologies of composite nanofibers were smooth when MSNs content was 2 wt%, 5 wt%, 10 wt%, while their surface morphologies were irregular as MSNs content increased to 30 wt%. MSNs were encapsulated into PLLA nanofibers when MSNs content was 2 wt%, 5 wt%, 10 wt%. The average tensile strength of 10 wt% PLLA/MSNs composite nanofibers could reach 4. 74 MPa. Thus, the prepared MSNs containing nanofiber is particularly promising for drug delivery applications.