Identifying and targeting angiogenesis-related microRNAs in ovarian cancer

被引：44

作者：

Chen, Xiuhui ^{[1
,2
]}

Mangala, Lingegowda S. ^{[1
,3
]}

Mooberry, Linda ^{[4
]}

Bayraktar, Emine ^{[1
,3
]}

Dasari, Santosh K. ^{[1
]}

Ma, Shaolin ^{[1
]}

Ivan, Cristina ^{[3
,5
]}

Court, Karem A. ^{[1
]}

Rodriguez-Aguayo, Cristian ^{[3
,5
]}

Bayraktar, Recep ^{[5
]}

Raut, Sangram ^{[4
]}

Sabnis, Nirupama ^{[4
]}

Kong, Xianchao ^{[2
]}

Yang, Xianbin ^{[6
]}

Lopez-Berestein, Gabriel ^{[3
,5
]}

Lacko, Andras G. ^{[4
,7
]}

Sood, Anil K. ^{[1
,3
,8
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Harbin, Heilongjiang, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNAs, Houston, TX 77030 USA

[4] Univ North Texas, Hlth Sci Ctr, Dept Physiol & Anat, Ft Worth, TX USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[6] AM Biotechnol, Houston, TX USA

[7] Univ North Texas, Hlth Sci Ctr, Dept Pediat, Ft Worth, TX USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

ONCOGENE | 2019年 / 38卷 / 33期

基金：

美国国家卫生研究院;

关键词：

HIGH-DENSITY-LIPOPROTEIN; ENDOTHELIAL GROWTH-FACTOR; TUMOR-GROWTH; MIR-204; DELIVERY; EXPRESSION; PACLITAXEL; THERAPY; THROMBOSPONDIN-1; IDENTIFICATION;

D O I：

10.1038/s41388-019-0862-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor angiogenesis and offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1 (SCARB1), reconstituted high-density lipoprotein-nanoparticles (rHDL-NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor angiogenesis.

引用

页码：6095 / 6108

页数：14

共 53 条

[1] Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies - A review
Al-Abd, Ahmed M.
Alamoudi, Abdulmohsin J.
Abdel-Naim, Ashraf B.
Neamatallah, Thikryat A.
Ashour, Osama M.
[J]. JOURNAL OF ADVANCED RESEARCH, 2017, 8 (06) : 591 - 605
[2] Intraperitoneal cisplatin and paclitaxel in ovarian cancer
Armstrong, DK
Bundy, B
Wenzel, L
Huang, HQ
Baergen, R
Lele, S
Copeland, LJ
Walker, JL
Burger, RA
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (01) : 34 - 43
[3] Integrated genomic analyses of ovarian carcinoma
Bell, D.
Berchuck, A.
Birrer, M.
Chien, J.
Cramer, D. W.
Dao, F.
Dhir, R.
DiSaia, P.
Gabra, H.
Glenn, P.
Godwin, A. K.
Gross, J.
Hartmann, L.
Huang, M.
Huntsman, D. G.
Iacocca, M.
Imielinski, M.
Kalloger, S.
Karlan, B. Y.
Levine, D. A.
Mills, G. B.
Morrison, C.
Mutch, D.
Olvera, N.
Orsulic, S.
Park, K.
Petrelli, N.
Rabeno, B.
Rader, J. S.
Sikic, B. I.
Smith-McCune, K.
Sood, A. K.
Bowtell, D.
Penny, R.
Testa, J. R.
Chang, K.
Dinh, H. H.
Drummond, J. A.
Fowler, G.
Gunaratne, P.
Hawes, A. C.
Kovar, C. L.
Lewis, L. R.
Morgan, M. B.
Newsham, I. F.
Santibanez, J.
Reid, J. G.
Trevino, L. R.
Wu, Y. -Q.
Wang, M.
[J]. NATURE, 2011, 474 (7353) : 609 - 615
[4] Future options of anti-angiogenic cancer therapy
Cao, Yihai
[J]. CHINESE JOURNAL OF CANCER, 2016, 35
[5] Role for miR-204 in human pulmonary arterial hypertension
Courboulin, Audrey
Paulin, Roxane
Giguere, Nellie J.
Saksouk, Nehme
Perreault, Tanya
Meloche, Jolyane
Paquet, Eric R.
Biardel, Sabrina
Provencher, Steeve
Cote, Jacques
Simard, Martin J.
Bonnet, Sebastien
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (03) : 535 - 548
[6] Dey N, 2015, AM J TRANSL RES, V7, P1675
[7] A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis
Dunn, Louise L.
Simpson, Philippa J. L.
Prosser, Hamish C.
Lecce, Laura
Yuen, Gloria S. C.
Buckle, Andrew
Sieveking, Daniel P.
Vanags, Laura Z.
Lim, Patrick R.
Chow, Renee W. Y.
Lam, Yuen Ting
Clayton, Zoe
Bao, Shisan
Davies, Michael J.
Stadler, Nadina
Celermajer, David S.
Stocker, Roland
Bursill, Christina A.
Cooke, John P.
Ng, Martin K. C.
[J]. DIABETES, 2014, 63 (02) : 675 - 687
[8] Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer
Flores-Perez, Ali
Marchat, Laurence A.
Rodriguez-Cuevas, Sergio
Bautista-Pina, Veronica
Hidalgo-Miranda, Alfredo
Arechaga Ocampo, Elena
Sierra Martinez, Monica
Palma-Flores, Carlos
Fonseca-Sanchez, Miguel A.
Astudillo-de la Vega, Horacio
Ruiz-Garcia, Erika
Antonio Gonzalez-Barrios, Juan
Perez-Plasencia, Carlos
Streber, Maria L.
Lopez-Camarillo, Cesar
[J]. SCIENTIFIC REPORTS, 2016, 6
[9] Role of angiogenesis in tumor growth and metastasis
Folkman, J
[J]. SEMINARS IN ONCOLOGY, 2002, 29 (06) : 15 - 18
[10] Identification and consequences of miRNA-target interactions - beyond repression of gene expression
Hausser, Jean
Zavolan, Mihaela
[J]. NATURE REVIEWS GENETICS, 2014, 15 (09) : 599 - 612

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