Cytomorphology of intraductal papillary neoplasm of the biliary tract

被引:3
作者
Canepa, Mariana [1 ,2 ]
Yao, Ruisheng [3 ]
Nam, Ga H. [1 ,2 ]
Patel, Nimesh R. [1 ,2 ]
Pisharodi, Latha [1 ,2 ]
机构
[1] Brown Univ, Dept Pathol & Lab Med, Warren Alpert Med Sch, Providence, RI 02912 USA
[2] Rhode Isl Hosp, Dept Pathol & Lab Med, 593 Eddy St,APC 12, Providence, RI 02903 USA
[3] Kent Hosp, Dept Pathol & Lab Med, Warwick, RI USA
关键词
Intraductal neoplasm of the biliary tract; papillary; bile duct; cytology; IPNB; BILE-DUCT; MUCINOUS NEOPLASM; RESPECT;
D O I
10.1002/dc.24212
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Intraductal papillary neoplasms of the bile duct (IPNBs) are papillary epithelial proliferations with delicate fibrovascular cores within dilated bile ducts. They are thought to be premalignant lesions with potential to progress invasive tumors. To our knowledge, there are no prior descriptions of IPNB cytomorphology. A 58-year-old male presented with painless jaundice and elevated liver function tests was found to have an intraluminal mass within the left hepatic duct. A bile duct brushing diagnosed as "atypical cells present" showed a cellular specimen composed of papillary groups and linear strips of mostly cuboidal/columnar cells with mild atypia and vacuolated cytoplasm. A left hepatic lobectomy including extrahepatic bile ducts showed the mass consisted of papillary cores lined by pancreatobiliary-type epithelium with mild-to-severe atypia, consistent with IPNB with a focus suspicious for invasion. The cytomorphologic features described in the current case suggest intraductal papillary neoplasm but may not be specific since similar features could be seen in other bile duct tumors and even in nonneoplastic conditions such as stent or cholelithiasis. However, it is worthwhile to report papillary hyperplasia with atypia in common bile duct brushings in order to avoid a false-negative diagnosis, especially in the context of a filling defect by images which does not appear to be a stone.
引用
收藏
页码:922 / 926
页数:5
相关论文
共 50 条
[41]   Pre-invasive intraductal papillary neoplasm of the pancreatobiliary system [J].
Nakanuma, Yasuni .
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2016, 40 (02) :133-135
[42]   Ruptured Oncocytic Intraductal Papillary Neoplasm: Think Beyond the Pancreas [J].
Jensen, Christopher W. ;
Worhunsky, David J. ;
Triadafilopoulos, George ;
Bingham, David B. ;
Visser, Brendan C. .
DIGESTIVE DISEASES AND SCIENCES, 2019, 64 (06) :1436-1438
[43]   Intraductal Papillary Neoplasm of the Bile Duct: A Rare Disease and Presentation [J].
Le, Alexander ;
Mathew, Anna ;
Khrais, Ayham ;
Khmelnitsky, Irina ;
Vossough, Sima .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (02)
[44]   Diagnostic performance of CT and MRI in distinguishing intraductal papillary neoplasm of the bile duct from cholangiocarcinoma with intraductal papillary growth [J].
Yubao Liu ;
Xiaomei Zhong ;
Lifen Yan ;
Junhui Zheng ;
Zaiyi Liu ;
Changhong Liang .
European Radiology, 2015, 25 :1967-1974
[45]   Intraductal papillary neoplasm of the bile duct: A rarity [J].
Bal, Munita Meenu ;
Goel, Mahesh ;
Ramadwar, Mukta ;
Deodhar, Kedar .
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2014, 57 (01) :144-145
[46]   Biliary Intraductal Papillary-mucinous Neoplasm Diagnosed by Peroral Direct Cholangioscopy Using a Slim Upper Endoscope (With Video) [J].
Zou, Xiao-Ping ;
Zhang, Ming ;
Li, Wen ;
Wu, Yu-lin .
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, 2011, 21 (05) :E263-E265
[47]   Green Sludge: Intraductal Papillary Mucinous Neoplasm of the Bile Duct Presenting with Intermittent Biliary Obstruction Due to Abundant Mucus [J].
Abhishek Choudhary ;
Monique T. Barakat ;
Julie N. Leal ;
Christine Y. Louie ;
Brendan C. Visser ;
Subhas Banerjee .
Digestive Diseases and Sciences, 2017, 62 :1897-1900
[48]   Gallbladder papillary neoplasms share pathological features with intraductal papillary neoplasm of the bile duct [J].
Wan, Xueshuai ;
Shi, Jie ;
Wang, Anqiang ;
Xie, Yuan ;
Yang, Xiaobo ;
Zhu, Chengpei ;
Zhang, Haohai ;
Wu, Liangcai ;
Wang, Shanshan ;
Huang, Hanchun ;
Lin, Jianzhen ;
Zheng, Yongchang ;
Liang, Zhiyong ;
Sang, Xinting ;
Zhao, Haitao .
ONCOTARGET, 2017, 8 (19) :31532-31539
[49]   Upregulation of follistatin and low apoptotic activity in intraductal oncocytic papillary neoplasm of the pancreatobiliary system [J].
Nakahodo, Jun ;
Fukumura, Yuki ;
Saito, Tsuyoshi ;
Hirabayashi, Kenichi ;
Doi, Reiko ;
Hayashi, Takuo ;
Yao, Takashi .
SCIENTIFIC REPORTS, 2020, 10 (01)
[50]   A case series of intraductal papillary neoplasms of the pancreas and biliary tract: a tertiary center experience [J].
Venkata, Gana Krishna Kiran Nandipalli ;
Waghray, Rachana ;
Ayesha, Sobiya M. ;
Thumma, Venu M. ;
Nagari, Bheerappa ;
Uppin, Shantveer G. ;
Boddula, Prashanth ;
Patnaik, Sujata ;
Uppin, Megha S. .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2023, 16 (10) :226-234