Oscillations of Skin Microvascular Blood Flow in Patients with Asthma

被引：10

作者：

Tikhonova, Irina V. ^{[1
]}

Kosyakova, Ninel I. ^{[2
]}

Tankanag, Arina V. ^{[1
]}

Chemeris, Nikolai K. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Moscow Region, Russia

[2] Russian Acad Sci, Hosp Pushchino Sci Ctr, Pushchino 142290, Moscow Region, Russia

来源：

MICROCIRCULATION | 2016年 / 23卷 / 01期

关键词：

microcirculation; skin blood flow oscillations; laser Doppler flowmetry; postocclusive reactive hyperemia; time-amplitude analysis; bronchial asthma; lung obstruction; REACTIVE HYPEREMIA; PERFUSION SIGNAL; SMALL AIRWAYS; HEALTHY; ENDOTHELIUM; VASCULARITY; DISEASE;

D O I：

10.1111/micc.12252

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveThis research is aimed at studying the features of skin blood flow oscillations in patients with severe persistent atopic BA during a period of fine control over symptoms. MethodsThe study of microcirculation was carried out by LDF at rest and in response to a transient ischemia in 20 patients. The time-amplitude adaptive wavelet analysis of the blood flow oscillations was conducted to elucidate the peculiarities of microcirculatory regulation system functioning. ResultsNo significant changes were revealed for SBP and the oscillation amplitudes in the cardiac (0.6-2Hz) and respiratory (0.145-0.6Hz) intervals, both at rest and in response to transient ischemia, in patients compared to the control group. A consistent twofold decrease in the oscillation amplitudes was found in the neurogenic (0.021-0.052Hz) interval at rest, as well as in the myogenic (0.052-0.145Hz) and NO-dependent endothelial (0.0095-0.021Hz) intervals both at rest and during the postocclusive reactive hyperemia in patients with lung obstruction (FEV1<80%) in comparison with a control group. ConclusionsThe amplitudes of skin blood flow oscillations in the myogenic, neurogenic and NO-dependent endothelial intervals in patients with obstruction are different from those in patients without obstruction.

引用

页码：33 / 43

页数：11

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