Primary and Secondary T-cell Lymphomas of the Breast Clinico-pathologic Features of 11 Cases

被引:53
作者
Gualco, Gabriela [1 ]
Chioato, Lucimara [1 ]
Harrington, William J., Jr. [2 ,3 ]
Weiss, Lawrence M. [4 ]
Bacchi, Carlos E. [1 ]
机构
[1] Consultoria Patol, BR-18602010 Sao Paulo, Brazil
[2] Univ Miami, Miller Sch Med, Dept Hematol, Miami, FL 33136 USA
[3] Fogarty Int Ctr AIDS & TB Program, Sylvester Canc Ctr, Miami, FL USA
[4] City Hope Natl Med Ctr, Div Pathol, Duarte, CA 91010 USA
关键词
malignant lymphoma; breast T-cell lymphoma; extranodal; non-Hodgkin lymphoma; immunohistochemistry; NON-HODGKINS-LYMPHOMA; IMPLANTS; CLASSIFICATION; ADJACENT; CANCER; MASS;
D O I
10.1097/PAI.0b013e318195286d
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Breast involvement by non-Hodgkin lymphomas is rare, and exceptional for T-cell lymphomas; we studied the morphologic, immunophenotypic, and clinical features of 11 patients with T-cell non-Hodgkin lymphomas involving the breast. Four cases fulfilled the definition criteria for primary breast lymphomas, 3 females and 1 male, with a median age of 51 years. One primary breast lymphomas was T-cell lymphoma unspecified, other was subcutaneous panniculitis-like T-cell lymphoma, and 2 cases were anaplastic large cell lymphomas. One of the anaplastic large cell lymphoma cases was found surrounding a silicone breast implant and presented as clinically as mastitis; whereas the other case occurred in a man. T-cell lymphoma secondarily involved the breast in 7 patients, all women and 1 bilateral, with a median age of 29 years. These secondary breast lymphomas occurred as part of widespread nodal or leukemic disease. Three patients had adult T-cell leukemia/lymphoma, including the patient with bilateral lesions, 3 others had precursor T-lymphoblastic lymphoma/leukemia, and the other presented with a peripheral-T-cell lymphoma nonotherwise specified type. Breast T-cell lymphomas are very infrequent and are morphologically and clinically heterogeneous.
引用
收藏
页码:301 / 306
页数:6
相关论文
共 37 条
[1]   T-cell lymphoma presenting in the breast: A histologic, immunophenotypic and molecular genetic study of four cases [J].
Aguilera, NSI ;
Tavassoli, FA ;
Chu, WS ;
Abbondanzo, SL .
MODERN PATHOLOGY, 2000, 13 (06) :599-605
[2]   NON-HODGKINS-LYMPHOMA INVOLVING THE BREAST [J].
ARBER, DA ;
SIMPSON, JF ;
WEISS, LM ;
RAPPAPORT, H .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1994, 18 (03) :288-295
[3]  
Au WY, 1997, HEMATOL ONCOL, V15, P33, DOI 10.1002/(SICI)1099-1069(199702)15:1<33::AID-HON595>3.0.CO
[4]  
2-K
[5]  
Behele S, 2007, INDIAN J PATHOL MICR, V50, P816
[6]  
Carneiro-Proietti Anna Bárbara F., 2002, Rev. Soc. Bras. Med. Trop., V35, P499, DOI 10.1590/S0037-86822002000500013
[7]  
Chan WC, 1997, BLOOD, V89, P3909
[8]  
COHEN PL, 1991, CANCER-AM CANCER SOC, V67, P1359, DOI 10.1002/1097-0142(19910301)67:5<1359::AID-CNCR2820670515>3.0.CO
[9]  
2-4
[10]   FOLLICULAR LYMPHOMA ADJACENT TO FOREIGN-BODY GRANULOMATOUS INFLAMMATION AND FIBROSIS SURROUNDING SILICONE BREAST PROSTHESIS [J].
COOK, PD ;
OSBORNE, BM ;
CONNOR, RL ;
STRAUSS, JF .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (06) :712-717