The promise of chimeric antigen receptor T cells (CARTs) in leukaemia

被引：19

作者：

Orlowski, Robert J. ^{[1
]}

Porter, David L. ^{[1
]}

Frey, Noelle V. ^{[1
]}

机构：

[1] Univ Penn, Dept Hematol Oncol, Philadelphia, PA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2017年 / 177卷 / 01期

关键词：

chimeric antigen receptor T cells; immunotherapy; leukaemia; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; CYTOKINE RELEASE SYNDROME; B-CELL; ADOPTIVE IMMUNOTHERAPY; CANCER-IMMUNOTHERAPY; ENHANCED SURVIVAL; PROGNOSTIC INDEX; PD-1; BLOCKADE; CD19;

D O I：

10.1111/bjh.14475

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The success of genetically engineered T cells that express chimeric antigen receptors ( CARTs) has been a momentous step forward in harnessing the potent cancer fighting abilities of the immune system. The efficacy seen in relapsed/refractory ( r/r) acute lymphoblastic leukaemia ( ALL), not only by inducing remission, but also in maintaining long-term disease control, has been unprecedented. While the foundation for this approach has been firmly set in place, continued development will improve the efficacy, toxicity and applicability to other malignancies of this new class of 'living drugs'. In this review, we provide a comprehensive overview of the most current clinical trial data in both acute and chronic leukaemias, and discuss some of the potential ways to enhance the activity and safety of CART therapy going forward.

引用

页码：13 / 26

页数：14

共 94 条

[1]

[Anonymous], 2016, SEER STAT FACT SHEET

[2] Multiparameter comparative analysis reveals differential impacts of various cytokines on CART cell phenotype and function ex vivo and in vivo [J].

Xu, Xiao-Jun ;

Song, De-Gang ;

Poussin, Mathilde ;

Ye, Qunrui ;

Sharma, Prannda ;

Rodriguez-Garcia, Alba ;

Tang, Yong-Min ;

Powell, Daniel J. .

ONCOTARGET, 2016, 7 (50) :82354-82368

[3] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[4] Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion [J].

Bengsch, Bertram ;

Johnson, Andy L. ;

Kurachi, Makoto ;

Odorizzi, Pamela M. ;

Pauken, Kristen E. ;

Attanasio, John ;

Stelekati, Erietta ;

McLane, Laura M. ;

Paley, Michael A. ;

Delgoffe, Greg M. ;

Wherry, E. John .

IMMUNITY, 2016, 45 (02) :358-373

[5] Prognostic index for adult patients with acute myeloid leukemia in first relapse [J].

Breems, DA ;

Van Putten, WLJ ;

Huijgens, PC ;

Ossenkoppele, GJ ;

Verhoef, GEG ;

Verdonck, LF ;

Vellenga, E ;

De Greef, G ;

Jacky, E ;

Van der Lelie, J ;

Boogaerts, MA ;

Löwenberg, B .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1969-1978

[6] Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial [J].

Brentjens, Renier ;

Yeh, Raymond ;

Bernal, Yvette ;

Riviere, Isabelle ;

Sadelain, Michel .

MOLECULAR THERAPY, 2010, 18 (04) :666-668

[7] Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias [J].

Brentjens, Renier J. ;

Riviere, Isabelle ;

Park, Jae H. ;

Davila, Marco L. ;

Wang, Xiuyan ;

Stefanski, Jolanta ;

Taylor, Clare ;

Yeh, Raymond ;

Bartido, Shirley ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Bernal, Yvette ;

Pegram, Hollie ;

Przybylowski, Mark ;

Hollyman, Daniel ;

Usachenko, Yelena ;

Pirraglia, Domenick ;

Hosey, James ;

Santos, Elmer ;

Halton, Elizabeth ;

Maslak, Peter ;

Scheinberg, David ;

Jurcic, Joseph ;

Heaney, Mark ;

Heller, Glenn ;

Frattini, Mark ;

Sadelain, Michel .

BLOOD, 2011, 118 (18) :4817-4828

[8] INTERLEUKIN-3 STIMULATES PROLIFERATION AND TRIGGERS ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULE-1 GENE ACTIVATION OF HUMAN ENDOTHELIAL-CELLS [J].

BRIZZI, MF ;

GARBARINO, G ;

ROSSI, PR ;

PAGLIARDI, GL ;

ARDUINO, C ;

AVANZI, GC ;

PEGORARO, L .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2887-2892

[9] Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease [J].

Brudno, Jennifer N. ;

Somerville, Robert P. T. ;

Shi, Victoria ;

Rose, Jeremy J. ;

Halverson, David C. ;

Fowler, Daniel H. ;

Gea-Banacloche, Juan C. ;

Pavletic, Steven Z. ;

Hickstein, Dennis D. ;

Lu, Tangying L. ;

Feldman, Steven A. ;

Iwamoto, Alexander T. ;

Kurlander, Roger ;

Maric, Irina ;

Goy, Andre ;

Hansen, Brenna G. ;

Wilder, Jennifer S. ;

Blacklock-Schuver, Bazetta ;

Hakim, Frances T. ;

Rosenberg, Steven A. ;

Gress, Ronald E. ;

Kochenderfer, James N. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1112-+

[10] Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia [J].

Burger, J. A. ;

Tedeschi, A. ;

Barr, P. M. ;

Robak, T. ;

Owen, C. ;

Ghia, P. ;

Bairey, O. ;

Hillmen, P. ;

Bartlett, N. L. ;

Li, J. ;

Simpson, D. ;

Grosicki, S. ;

Devereux, S. ;

McCarthy, H. ;

Coutre, S. ;

Quach, H. ;

Gaidano, G. ;

Maslyak, Z. ;

Stevens, D. A. ;

Janssens, A. ;

Offner, F. ;

Mayer, J. ;

O'Dwyer, M. ;

Hellmann, A. ;

Schuh, A. ;

Siddiqi, T. ;

Polliack, A. ;

Tam, C. S. ;

Suri, D. ;

Cheng, M. ;

Clow, F. ;

Styles, L. ;

James, D. F. ;

Kipps, T. J. ;

Keating, Michael ;

Jen, Jie ;

Jindra, Pavel ;

Simkovic, Martin ;

Braester, Andrei ;

Ruchlemer, Rosa ;

Foa, Roberto ;

Semenzato, Gianpietro ;

Hawkins, Timothy ;

Atanasio, Carolina Moreno ;

Demirkan, Fatih ;

Kaynar, Leylagul ;

Pylypenko, Halyna ;

Fox, Christopher ;

Thirman, Michael ;

Campbell, Philip .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (25) :2425-2437

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